ArticleThe Journal of clinical investigation1997
A non-MHC locus essential for autoimmune type I diabetes in the Komeda Diabetes-Prone rat.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- The role and mechanism of mesenchymal stem cells in immunomodulation of type 1 diabetes mellitus and its complications: recent research progress and challenges: a review.Stem cell research & therapy · 2025Review
- Current advancement in the preclinical models used for the assessment of diabetic neuropathy.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Review
- Contribution of animal models to diabetes research: Its history, significance, and translation to humans.Journal of diabetes investigation · 2023Review
- Preclinical models for Type 1 Diabetes Mellitus - A practical approach for research.International journal of medical sciences · 2023Review
- Experimental animal models for diabetes and its related complications-a review.Laboratory animal research · 2021Review
- Article
- Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats.Genes and immunity · 2012Article
- Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat.Experimental diabetes research · 2012Review
- Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2.Comparative medicine · 2008Article
- LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.Diabetes · 2005Article
- Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Polymorphic variation in the CBLB gene in human type 1 diabetes.Genes and immunity · 2004Article
- Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family.The Journal of clinical investigation · 1998Article
- Correlation between genetic and cytogenetic maps of the rat.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Long-Evans Tokushima Lean (LETL) rat, characterized by rapid onset of insulin-dependent (type I) diabetes mellitus (IDDM), no sex difference in the incidence of IDDM, autoimmune destruction of pancreatic beta cells, and no significant T cell lymphopenia, is a desirable animal model for human IDDM. We have established a diabetes-prone substrain of the LETL rat, named Komeda Diabetes-Prone (KDP) rat, showing a 100% development of moderate to severe insulitis within 220 d of age. The cumulative frequency of IDDM was 70% at 120 d of age, and reached 82% within 220 d of age. Here, we performed the first genome-wide scan for non-MHC IDDM susceptibility genes in this strain. The analysis of three crosses has led to the revelation of a major IDDM susceptibility gene, termed Iddm/kdp1, on rat chromosome (Chr) 11. Homozygosity for the KDP allele at this locus is shown to be essential for the development of moderate to severe insulitis and the onset of IDDM. Comparative mapping suggests that the homologues of Iddm/ kdp1 are located on human Chr 3 and mouse Chr 16 and would therefore be different from previously reported IDDM susceptibility genes.
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