ArticleThe American journal of pathology1997
Loss of type IV collagen alpha 5 and alpha 6 chains in human invasive prostate carcinomas.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Collagen type IV alpha 6 promotes tumor progression and chemoresistance in ovarian cancer by activating the discoidin domain receptor 1 pathway.Oncogenesis · 2025Article
- Morphologic Pattern, Frequency, and Spatial Distribution of Lymphovascular Invasion Foci in Radical Prostatectomy Specimens.International journal of surgical pathology · 2023Article
- Methylation of the epigenetic JMJD2D protein by SET7/9 promotes prostate tumorigenesis.Frontiers in oncology · 2023Article
- Differential expression ofOncology letters · 2021Article
- Identified the novel resistant biomarkers for taxane-based therapy for triple-negative breast cancer.International journal of medical sciences · 2021Article
- Zonal regulation of collagen-type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry.The Prostate · 2020Article
- RHCG and TCAF1 promoter hypermethylation predicts biochemical recurrence in prostate cancer patients treated by radical prostatectomy.Oncotarget · 2017Article
- Proteomic Upregulation of Fatty Acid Synthase and Fatty Acid Binding Protein 5 and Identification of Cancer- and Race-Specific Pathway Associations in Human Prostate Cancer Tissues.Journal of Cancer · 2016Article
- Lamstatin--a novel inhibitor of lymphangiogenesis derived from collagen IV.Journal of cellular and molecular medicine · 2012Article
- Investigation of basement membrane proteins in a case of granular cell ameloblastoma.International journal of oral science · 2012Article
- Novel methods to identify biologically relevant genes for leukemia and prostate cancer from gene expression profiles.BMC genomics · 2010Article
- Article
- Inhibition of tumor angiogenesis by tumstatin: insights into signaling mechanisms and implications in cancer regression.Pharmaceutical research · 2008Review
- Differential expression of basement membrane collagen-IV alpha1 to alpha6 chains during oral carcinogenesis.Virchows Archiv : an international journal of pathology · 2006Article
- Inference of disease-related molecular logic from systems-based microarray analysis.PLoS computational biology · 2006Article
- Transcriptomes of human prostate cells.BMC genomics · 2006Article
- Loss of expression of type IV collagen alpha5 and alpha6 chains in colorectal cancer associated with the hypermethylation of their promoter region.The American journal of pathology · 2006Article
- The role of type IV collagen and basement membranes in cancer progression and metastasis.The American journal of pathology · 2006Article
- Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma.Virchows Archiv : an international journal of pathology · 2005Article
- Differential expression of basement membrane type-IV collagen alpha1, alpha2, alpha5 and alpha6 chains among the histological subtypes of adenoid cystic carcinoma.Virchows Archiv : an international journal of pathology · 2004Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type IV collagen, a major component of basement membranes, is organized in a network responsible for the mechanical resistance of the basement membranes. It also plays a key role in epithelial cell adhesion to basement membranes. This study was designed to investigate the distribution of type IV collagen alpha-chains in normal, preneoplastic, and malignant prostate basement membranes. For this purpose, immunohistochemistry using specific antibodies raised against the different alpha-chains of type IV collagen was performed in eight normal samples, six prostatic intraepithelial neoplasia, and 20 malignant lesions of the prostate. Our results demonstrate the presence of the "novel" alpha 5 (IV) and alpha 6 (IV) chains along with the "classical" alpha 1 (IV)/alpha 2 (IV) chains in the basement membrane of the normal prostate gland. The alpha 3 (IV) chain was never detected in any prostate specimen. Prostatic intraepithelial neoplasia showed a similar immunostaining pattern to that found in normal glands. In cancer gland basement membranes, we demonstrate for the first time a specific loss of the alpha 5 (IV) and alpha 6 (IV) chains, whereas the classical alpha 1 (IV) and alpha 2 (IV) chains were consistently exhibited. Additionally, type VII collagen colocalized with alpha 5 (IV) collagen chain, and these two proteins, which were always observed in normal and prostatic intraepithelial neoplasia gland basement membranes, were lost in invasive carcinoma basement membranes. This observation raises questions about the possible association or cooperation between alpha 5 (IV)/alpha 6 (IV) chains and anchoring fibrils in prostate glands basement membrane.
Indexed as
Identifiers
9327743PMC1858039W55854728What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.