ArticleThe American journal of pathology1997
CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 238 citations in OpenAlex.
- Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers.Antimicrobial agents and chemotherapy · 2000Trial
- Predictors of hippocampal tauopathy in people with and at risk for human immunodeficiency virus infection.Journal of neurovirology · 2023Article
- Microglia in antiviral immunity of the brain and spinal cord.Seminars in immunology · 2022Review
- Cognitive Function Among Antiretroviral Treatment-Naive Individuals Infected With Human Immunodeficiency Virus Type 1 Subtype G Versus CRF02_AG in Nigeria.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- HIV-associated synaptic degeneration.Molecular brain · 2017Review
- Development and characterization of a human microglia cell model of HIV-1 infection.Journal of neurovirology · 2017Article
- HIV-associated neurocognitive disorders: recent advances in pathogenesis, biomarkers, and treatment.F1000Research · 2017Review
- Envelope gene evolution and HIV-1 neuropathogenesis.Journal of neuroinfectious diseases · 2015Article
- The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure.AIDS (London, England) · 2014Review
- Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression.Molecular imaging and biology · 2013Article
- Human immunodeficiency virus-associated depression: contributions of immuno-inflammatory, monoaminergic, neurodegenerative, and neurotrophic pathways.Journal of neurovirology · 2013Review
- Neuronal toxicity in HIV CNS disease.Future virology · 2012Article
- Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain.BMC neuroscience · 2012Article
- Genetic knockouts suggest a critical role for HIV co-receptors in models of HIV gp120-induced brain injury.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- Review
- Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity.Toxicology and applied pharmacology · 2011Article
- The effect of gp120 on morphine's antinociceptive and neurophysiological actions.Brain, behavior, and immunity · 2011Article
- Article
- Article
- Mitogen-activated protein kinase p38 in HIV infection and associated brain injury.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Entry of the type 1 human immunodeficiency virus into most cells requires the presence of the CD4 protein in combination with one of several recently described co-receptors. CXCR-4 (fusin) was the first identified, and it serves as co-receptor for T-cell-line tropic (T-tropic) HIV-1 isolates. To determine the expression of CXCR-4 in the brain, a major target of HIV pathology, we used immunohistochemistry and reverse transcriptase polymerase chain reaction with CXCR-4-specific antibodies and probes. We found that CXCR-4 was expressed in several cell types in brain, but notably in neurons and microglia, a finding that was replicated in tissue culture. The study of the expression of CXCR-4 in the brain, which may be one of many chemokine receptors in the central nervous system, may provide further insight into the interactions between brain cells, pathogens, and the immune system, and help understand the pathogenesis of HIV dementia.
Indexed as
Identifiers
9327737PMC1858037W1573398139What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.