ArticleThe American journal of pathology1997
Dedifferentiation of atrial cardiomyocytes as a result of chronic atrial fibrillation.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 147 citations in OpenAlex.
- Diabetic Atrial Cardiomyopathy: Pathogenesis, Diagnosis, Management, AI-Driven Diagnosis, and Risk Prediction.Journal of diabetes research · 2026Review
- Animal models of arrhythmia: classic electrophysiology to genetically modified large animals.Nature reviews. Cardiology · 2019Review
- EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication.Heart rhythm · 2017Review
- Assessment of atrial electromechanical interval using echocardiography after catheter ablation in patients with persistent atrial fibrillation.Journal of biomedical research · 2016Article
- EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2016Article
- Myocardial plasticity: cardiac development, regeneration and disease.Current opinion in genetics & development · 2016Review
- EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication.Journal of arrhythmia · 2016Article
- Atrophied cardiomyocytes and their potential for rescue and recovery of ventricular function.Heart failure reviews · 2016Review
- Myofibroblast secretome and its auto-/paracrine signaling.Expert review of cardiovascular therapy · 2016Review
- Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells.Scientific reports · 2015Article
- Cardiomyocyte Remodeling in Atrial Fibrillation and Hibernating Myocardium: Shared Pathophysiologic Traits Identify Novel Treatment Strategies?BioMed research international · 2015Review
- Glycogen and the propensity for atrial fibrillation: intrinsic anatomic differences in glycogen in the left and right atria in the goat heart.North American journal of medical sciences · 2014Article
- Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: insights from the three-dimensional virtual human atria.The Journal of physiology · 2013Article
- Cyclical stretch induces structural changes in atrial myocytes.Journal of cellular and molecular medicine · 2013Article
- Organ explant culture of neonatal rat ventricles: a new model to study gene and cell therapy.PloS one · 2013Article
- Analysis on differential gene expression data for prediction of new biological features in permanent atrial fibrillation.PloS one · 2013Article
- Triggers and anatomical substrates in the genesis and perpetuation of atrial fibrillation.Current cardiology reviews · 2012Review
- Loss of proteostatic control as a substrate for atrial fibrillation: a novel target for upstream therapy by heat shock proteins.Frontiers in physiology · 2012Article
- Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2011Review
- Recent clinical and experimental advances in atrial fibrillation.ISRN cardiology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic atrial fibrillation was induced in goats by electrical pacing. After 9 to 23 weeks of sustained atrial fibrillation, the morphology of the atrial structures was examined. The majority of the cardiomyocytes exhibited marked changes in their cellular substructures, with the replacement of sarcomeres by glycogen as the main characteristic. Using immuno-histochemical staining procedures, we assessed the expression and organization of contractile and cytoskeletal proteins in these cases and compared them with the expression and organization of these proteins in normal atria. Part of the atrial cardiomyocytes acquired a dedifferentiated phenotype, as deduced from the re-expression of alpha-smooth muscle actin, the disappearance of cardiotin, and the staining patterns of titin, which resembled those of embryonic cardiomyocytes. From these results we conclude that chronic atrial fibrillation induces myocardial dedifferentiation. This model of chronic atrial fibrillation in goats offers the possibility to study the time course of changes in cardiac structure during sustained atrial fibrillation and after cardioversion.
Indexed as
Identifiers
9327732PMC1858023W1821505083What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.