ArticleThe American journal of pathology1997
Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 59 citations in OpenAlex.
- Imaging angiogenesis in an intracerebrally induced model of brain macrometastasis using αNMR in biomedicine · 2023Article
- The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis.Journal of extracellular vesicles · 2020Article
- Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.Investigative ophthalmology & visual science · 2015Article
- Targeting the Achilles' heel of drug-resistant cancer stem cells.Cell cycle (Georgetown, Tex.) · 2014Article
- The role of vascular endothelial growth factor in wound healing.The Journal of surgical research · 2009Review
- Synergistic control of cell adhesion by integrins and syndecans.Nature reviews. Molecular cell biology · 2007Review
- Inhibition of endothelial cell survival and angiogenesis by protein kinase A.The Journal of clinical investigation · 2002Article
- Inhibition of tumor progression and neoangiogenesis using cyclic RGD-peptides in a chemically induced colon carcinoma in rats.Clinical & experimental metastasis · 2002Article
- Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritis.The American journal of pathology · 2002Article
- Adhesion of microvascular endothelial cells to metallic implant surfaces.Journal of materials science. Materials in medicine · 2000Article
- Role and localization of urokinase receptor in the formation of new microvascular structures in fibrin matrices.The American journal of pathology · 1999Article
- Current concepts of tumor-induced angiogenesis.Pathology oncology research : POR · 1998Review
- Adhesion molecules in rheumatoid arthritis.Springer seminars in immunopathology · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Accumulating evidence indicates that endothelial cell integrins that bind to the matrix proteins associated with inflammation and wound healing are involved in the process of angiogenesis. The integrins containing the alpha v subunit appear to be particularly important. To study the involvement of these receptors in human angiogenesis, a model of wound-associated human angiogenesis was established in human skin transplanted onto severe combined immunodeficient (SCID) mice. Using this model, we studied the expression of several alpha v integrins and tested the hypothesis that blockage of the alpha v beta 3 integrin would inhibit human angiogenesis during human wound healing. These studies revealed that the alpha v beta 3, alpha v beta 5, and alpha v beta 6 integrins are up-regulated briefly during wound angiogenesis with different patterns of expression and that inhibition of the alpha v beta 3 integrin blocked new vessel formation during human wound healing.
Indexed as
Identifiers
9327731PMC1858044W2287029392What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.