ArticleThe American journal of pathology1997
Bile ductular damage induced by methylene dianiline inhibits oval cell activation.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 89 citations in OpenAlex.
- Liver Progenitor Cells: Cellular Origins, Plasticity, and Signaling Pathways in Liver Regeneration.Biology · 2025Review
- Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns.Annual review of pathology · 2020Review
- miR-133b Regulation of Connective Tissue Growth Factor: A Novel Mechanism in Liver Pathology.The American journal of pathology · 2016Article
- Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure.Scientific reports · 2016Article
- Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease.Gastroenterology · 2015Review
- Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury.PloS one · 2015Article
- The unique polarity phenotype of hepatocytes.Experimental cell research · 2014Review
- The liver is a peculiar organ when it comes to stem cells.The American journal of pathology · 2014Article
- Hepatocyte polarity.Comprehensive Physiology · 2013Review
- Article
- Phenotypic fidelity (or not?) of epithelial cells in the liver.Hepatology (Baltimore, Md.) · 2012Article
- Spontaneous repopulation of β-catenin null livers with β-catenin-positive hepatocytes after chronic murine liver injury.Hepatology (Baltimore, Md.) · 2011Article
- Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad.Seminars in cancer biology · 2011Review
- Liver regeneration: alternative epithelial pathways.The international journal of biochemistry & cell biology · 2011Review
- Potential applications for cell regulatory factors in liver progenitor cell therapy.The international journal of biochemistry & cell biology · 2011Review
- Expression of hepatocytic- and biliary-specific transcription factors in regenerating bile ducts during hepatocyte-to-biliary epithelial cell transdifferentiation.Comparative hepatology · 2010Article
- The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiation.The American journal of pathology · 2010Article
- Tissue-derived stem and progenitor cells.Stem cells international · 2010Article
- Isolation and characterization of hepatic stem cells, or "oval cells," from rat livers.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development.Laboratory investigation; a journal of technical methods and pathology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Administration of 2-acetylaminofluorene (2-AAF) given before a two-thirds partial hepatectomy (PHx), results in suppression of hepatocyte proliferation and stimulation of oval cell proliferation. Our objective in this study was to examine the oval cell response and associated alpha-fetoprotein (AFP) gene expression by combining 2-AAF with selective hepatic damage caused by either carbon tetrachloride (CCl4) exposure or by PHx. We also examined oval cell response with the above two protocols (2-AAF/CCl4 and 2-AAF/PHx) as affected by previous bile ductular damage caused by 4,4'-methylene dianiline (4,4'-diaminodiphenylmethane, DAPM) exposure. DAPM is an aromatic diamine, known to cause bile ductular damage in both humans and animals. Using the protocols of 2-AAF/ CCl4 and 2-AAF/PHx, when DAPM was given 24 hours before the hepatic injury, no oval cell proliferation was seen (histological) and AFP expression was not detected by Northern blot analysis. These results provide direct evidence that oval cells are closely associated with the biliary epithelial cells and supports the theory that hepatic oval cells may originate from cells derived from either intraportal or periportal ductules.
Indexed as
Identifiers
9327722PMC1858051W1903907703What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.