ArticleHeart (British Cardiac Society)1997
Serum urate and the risk of major coronary heart disease events.
Article in Heart (British Cardiac Society), 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 213 citations in OpenAlex.
- Pooled it
- Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies.BMJ (Clinical research ed.) · 2017Pooled it
- Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies.BMC cardiovascular disorders · 2016Pooled it
- Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis.PLoS medicine · 2005Pooled it
- Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension.Kidney & blood pressure research · 2012Trial
- Uric acid and long-term outcomes in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2009Trial
- Redefining Uric Acid and Cardiovascular Risk: Vascular Gout and Crystal-Driven Vascular Inflammation in Asymptomatic Hyperuricemia.JACC. Asia · 2026Review
- Serum uric acid: an independent risk factor for cardiovascular disease in Pakistani Punjabi patients.BMC cardiovascular disorders · 2024Observational
- A Study of Lipid Profile and the Correlation of Serum Uric Acid Levels in Patients With Hypertension.Cureus · 2024Article
- Uric Acid Levels, Number of Standard Modifiable Cardiovascular Risk Factors, and Prognosis in Patients With Coronary Artery Disease: A Large Cohort Study in Asia.Journal of the American Heart Association · 2023Article
- Uric Acid and Risk of Cardiovascular Disease and Mortality: A Longitudinal Cohort Study.Journal of Korean medical science · 2023Article
- Effect and correlation of patent vascular access flow on left ventricular hypertrophy in kidney transplant patients.International journal of cardiology. Heart & vasculature · 2022Article
- Retrospective Study from a Single Center to Evaluate the Association Between Sex and Serum Uric Acid Levels in 950 Patients with Atrial Fibrillation.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Association between gout and cardiovascular outcomes in adults with no history of cardiovascular disease: large data linkage study in New Zealand.BMJ medicine · 2022Article
- Change of serum uric acid and progression of cardiometabolic multimorbidity among middle aged and older adults: A prospective cohort study.Frontiers in public health · 2022Article
- Cumulative Serum Uric Acid and Its Time Course Are Associated With Risk of Myocardial Infarction and All-Cause Mortality.Journal of the American Heart Association · 2021Observational
- Early onset of hyperuricemia is associated with increased cardiovascular disease and mortality risk.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- Association of hyperuricemia and serum uric acid lowering therapy with mortality in hemodialysis patients.Renal failure · 2020Article
- Trends of venous thromboembolism risk before and after diagnosis of gout: a general population-based study.Rheumatology (Oxford, England) · 2020Article
- Hyperuricemia is a Risk Factor for One-Year Overall Survival in Elderly Female Patients with Acute Coronary Syndrome.Cardiovascular therapeutics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the relation between serum urate and the risk of major coronary heart disease events.
designA prospective study of a male cohort.
settingOne general practice in each of 24 British towns. SUBJECTS: 7688 men aged 40-59 years at screening.
main outcome measuresFatal and non-fatal coronary heart disease events.
resultsThere were 1085 major coronary heart disease events during the average follow up period of 16.8 years. Serum urate was significantly associated with a wide range of cardiovascular risk factors including body mass index, alcohol intake, antihypertensive treatment, pre-existing coronary heart disease, serum triglycerides, cholesterol, and diastolic blood pressure. There was a significant positive association between serum urate and risk of coronary heart disease after adjustment for lifestyle factors and disease indicators. This relation was attenuated to non-significance upon additional adjustment for diastolic blood pressure and serum total cholesterol: cholesterol appeared to be the critical factor in attenuating this relation. When the association between serum urate and risk of coronary heart disease was examined by presence and grade of pre-existing coronary heart disease, a positive association was seen only in men with previous definite myocardial infarction, even after full adjustment (P = 0.07).
conclusionsThe relation between serum urate and the risk of coronary heart disease depends heavily upon the presence of pre-existing myocardial infarction and widespread underlying atherosclerosis as well as the clustering of risk factors. Thus serum urate is not a truly independent risk factor for coronary heart disease. Raised serum urate appears to be an integral part of the cluster of risk factors associated with the insulin resistance syndrome that include obesity, raised serum triglycerides, and serum cholesterol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.