ArticleProceedings of the National Academy of Sciences of the United States of America1997
Arabidopsis thaliana mutants altered in homologous recombination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 41 citations in OpenAlex.
- Plant DNA recombinases: a long way to go.Journal of nucleic acids · 2010Article
- CENTRIN2 modulates homologous recombination and nucleotide excision repair in Arabidopsis.The Plant cell · 2004Article
- AtATM is essential for meiosis and the somatic response to DNA damage in plants.The Plant cell · 2003Article
- Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis.Genes & development · 2001Article
- AtSPO11-1 is necessary for efficient meiotic recombination in plants.The EMBO journal · 2001Article
- The maternal chromosome set is the target of the T-DNA in the in planta transformation of Arabidopsis thaliana.Genetics · 2000Article
- Stimulation of homologous recombination in plants by expression of the bacterial resolvase ruvC.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Homologous recombination contributes both to the generation of allelic diversity and to the preservation of genetic information. In plants, a lack of suitable experimental material has prevented studies of the regulatory and enzymatic aspects of recombination in somatic and meiotic cells. We have isolated nine Arabidopsis thaliana mutants hypersensitive to x-ray irradiation (xrs) and examined their recombination properties. For the three xrs loci described here, single recessive mutations were found to confer simultaneous hypersensitivities to the DNA-damaging chemicals mitomycin C (MMCs) and/or methyl methanesulfonate (MMSs) and alterations in homologous recombination. Mutant xrs9 (Xrays, MMSs) is reduced in both somatic and meiotic recombination and resembles yeast mutants of the rad52 epistatic group. xrs11 (Xrays, MMCs) is deficient in the x-ray-mediated stimulation of homologous recombination in somatic cells in a manner suggesting a specific signaling defect. xrs4 (Xrays, MMSs, MMCs) has a significant deficiency in somatic recombination, but this is accompanied by meiotic hyper-recombination. A corresponding phenotype has not been reported in other systems and thus this indicates a novel, plant-specific regulatory circuit linking mitotic and meiotic recombination.
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