ArticleProceedings of the National Academy of Sciences of the United States of America1997
Ca2+-independent inhibition of inositol trisphosphate receptors by calmodulin: redistribution of calmodulin as a possible means of regulating Ca2+ mobilization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 105 citations in OpenAlex.
- Calmodulin Mutations in Human Disease.Channels (Austin, Tex.) · 2023Review
- Metabolic profiling of Mytilus coruscus mantle in response of shell repairing under acute acidification.PloS one · 2023Article
- A novel assay to assess the effects of estrogen on the cardiac calmodulin binding equilibrium.Life sciences · 2022Article
- Phytate as a Phosphorus Nutrient with Impacts on Iron Stress-Related Gene Expression for Phytoplankton: Insights from the DiatomApplied and environmental microbiology · 2022Article
- NCS-1 is a regulator of calcium signaling in health and disease.Biochimica et biophysica acta. Molecular cell research · 2018Review
- Resident Calmodulin Primes NMDA Receptors for CaBiophysical journal · 2017Article
- IPCellular and molecular life sciences : CMLS · 2017Review
- Sense and specificity in neuronal calcium signalling.Biochimica et biophysica acta · 2015Review
- Visualizing CaMKII and CaM activity: a paradigm of compartmentalized signaling.Journal of molecular medicine (Berlin, Germany) · 2013Review
- CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Calmodulin binds HER2 and modulates HER2 signaling.Biochimica et biophysica acta · 2011Article
- mGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons.Cold Spring Harbor perspectives in biology · 2011Review
- IP(3) receptors: toward understanding their activation.Cold Spring Harbor perspectives in biology · 2010Review
- STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Inositol trisphosphate receptor Ca2+ release channels.Physiological reviews · 2007Review
- Free and bound intracellular calmodulin measurements in cardiac myocytes.Cell calcium · 2007Article
- Transient calcium and dopamine increase PKA activity and DARPP-32 phosphorylation.PLoS computational biology · 2006Article
- Signalling pathways in pollen germination and tube growth.Protoplasma · 2006Review
- Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium.The Journal of clinical investigation · 2006Article
- Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells.The Biochemical journal · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The interactions between calmodulin, inositol 1,4,5-trisphosphate (InsP3), and pure cerebellar InsP3 receptors were characterized by using a scintillation proximity assay. In the absence of Ca2+, 125I-labeled calmodulin reversibly bound to multiple sites on InsP3 receptors and Ca2+ increased the binding by 190% +/- 10%; the half-maximal effect occurred when the Ca2+ concentration was 184 +/- 14 nM. In the absence of Ca2+, calmodulin caused a reversible, concentration-dependent (IC50 = 3.1 +/- 0.2 microM) inhibition of [3H]InsP3 binding by decreasing the affinity of the receptor for InsP3. This effect was similar at all Ca2+ concentrations, indicating that the site through which calmodulin inhibits InsP3 binding has similar affinities for calmodulin and Ca2+-calmodulin. Calmodulin (10 microM) inhibited the Ca2+ release from cerebellar microsomes evoked by submaximal, but not by maximal, concentrations of InsP3. Tonic inhibition of InsP3 receptors by the high concentrations of calmodulin within cerebellar Purkinje cells may account for their relative insensitivity to InsP3 and limit spontaneous activation of InsP3 receptors in the dendritic spines. Inhibition of InsP3 receptors by calmodulin at all cytosolic Ca2+ concentrations, together with the known redistribution of neuronal calmodulin evoked by protein kinases and Ca2+, suggests that calmodulin may also allow both feedback control of InsP3 receptors and integration of inputs from other signaling pathways.
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