ArticleProceedings of the National Academy of Sciences of the United States of America1997
Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- ProS1-MerTK signaling in CD4 T cells: implications for TIL expansion and functionality.Oncoimmunology · 2025Article
- TAM family kinases as therapeutic targets at the interface of cancer and immunity.Nature reviews. Clinical oncology · 2023Review
- Review
- Lifting the innate immune barriers to antitumor immunity.Journal for immunotherapy of cancer · 2020Review
- TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting.Cancer immunology, immunotherapy : CII · 2020Review
- Coagulopathies and inflammatory diseases: '…glimpse of a Snark'.Current opinion in immunology · 2018Review
- TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy.Immunological reviews · 2017Review
- The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy.Cancers · 2016Review
- TAM receptor signaling in immune homeostasis.Annual review of immunology · 2015Review
- Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer.Inflammatory bowel diseases · 2014Review
- Biology of the TAM receptors.Cold Spring Harbor perspectives in biology · 2013Review
- T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.Immunity · 2013Article
- Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis.Neuron · 2012Article
- Macrophage-tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands.Cellular and molecular life sciences : CMLS · 2012Review
- Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection.The Journal of clinical investigation · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Extravascular procoagulant activity often accompanies cell-mediated immune responses and systemic administration of pharmacologic anticoagulants prevents cell-mediated delayed-type hypersensitivity reactions. These observations suggest a direct association between coagulation and cell-mediated immunity. The cytokine interleukin (IL)-4 potently suppresses cell-mediated immune responses, but its mechanism of action remains to be determined. Herein we demonstrate that the physiologic anticoagulant protein S is IL-4-inducible in primary T cells. Although protein S was known to inhibit the classic factor Va-dependent prothrombinase assembled by endothelial cells and platelets, we found that protein S also inhibits the factor Va-independent prothrombinase assembled by lymphoid cells. Thus, protein S-mediated down-regulation of lymphoid cell procoagulant activity may be one mechanism by which IL-4 antagonizes cell-mediated immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.