ArticleAmerican journal of human genetics1997
Association mapping of disease loci, by use of a pooled DNA genomic screen.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed.
- A genome-wide association scan for asthma in a general Australian population.Human genetics · 2008Trial
- Specific Differentially Methylated and Expressed Genes in People with Longevity Family History.Iranian journal of public health · 2021Article
- Deciphering the Genetic Diversity of Landraces With High-Throughput SNP Genotyping of DNA Bulks: Methodology and Application to the Maize 50k Array.Frontiers in plant science · 2020Article
- A Partially Phase-Separated Genome Sequence Assembly of theFrontiers in plant science · 2020Article
- A Novel Relationship for Schizophrenia, Bipolar, and Major Depressive Disorder. Part 8: a Hint from Chromosome 8 High Density Association Screen.Molecular neurobiology · 2017Article
- A novel relationship for schizophrenia, bipolar and major depressive disorder Part 5: a hint from chromosome 5 high density association screen.American journal of translational research · 2017Article
- Maximum-parsimony haplotype frequencies inference based on a joint constrained sparse representation of pooled DNA.BMC bioinformatics · 2013Article
- Genome association study of human chromosome 13 and susceptibility to coronary artery disease in a Chinese population.Journal of genetics · 2013Article
- An evaluation of allele frequency estimation accuracy using pooled sequencing data.International journal of computational biology and drug design · 2013Article
- Evaluation of allele frequency estimation using pooled sequencing data simulation.TheScientificWorldJournal · 2013Article
- Fast and accurate haplotype frequency estimation for large haplotype vectors from pooled DNA data.BMC genetics · 2012Article
- Optimality of group testing in the presence of misclassification.Biometrika · 2012Article
- Ice-COLD-PCR enables rapid amplification and robust enrichment for low-abundance unknown DNA mutations.Nucleic acids research · 2011Article
- Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.Annals of the New York Academy of Sciences · 2008Review
- The immunogenetics of multiple sclerosis.Immunogenetics · 2008Review
- Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission.BMC medical genetics · 2008Article
- Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping.BMC psychiatry · 2008Article
- The Finnish lapphund retinal atrophy locus maps to the centromeric region of CFA9.BMC veterinary research · 2007Article
- Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies.BMC genomics · 2007Article
- Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2006Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Genomic screening to map disease loci by association requires automation, pooling of DNA samples, and 3,000-6,000 highly polymorphic, evenly spaced microsatellite markers. Case-control samples can be used in an initial screen, followed by family-based data to confirm marker associations. Association mapping is relevant to genetic studies of complex diseases in which linkage analysis may be less effective and to cases in which multigenerational data are difficult to obtain, including rare or late-onset conditions and infectious diseases. The method can also be used effectively to follow up and confirm regions identified in linkage studies or to investigate candidate disease loci. Study designs can incorporate disease heterogeneity and interaction effects by appropriate subdivision of samples before screening. Here we report use of pooled DNA amplifications-the accurate determination of marker-disease associations for both case-control and nuclear family-based data-including application of correction methods for stutter artifact and preferential amplification. These issues, combined with a discussion of both statistical power and experimental design to define the necessary requirements for detecting of disease loci while virtually eliminating false positives, suggest the feasibility and efficiency of association mapping using pooled DNA screening.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.