ArticleGastroenterology1997
Helicobacter pylori Lewis expression is related to the host Lewis phenotype.
Article in Gastroenterology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 138 citations in OpenAlex.
- Lipopolysaccharide O-antigen profiles of Helicobacter pylori strains from Southwest China.BMC microbiology · 2023Article
- Molecular mimicry inWorld journal of gastroenterology · 2017Review
- The Prevalence of Helicobacter pylori Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence.BioMed research international · 2015Article
- Genotypic and phenotypic variation of Lewis antigen expression in geographically diverse Helicobacter pylori isolates.Helicobacter · 2011Article
- Prevalence of two homologous genes encoding glycosyltransferases of Helicobacter pylori in the United States and Japan.Journal of gastroenterology and hepatology · 2011Article
- Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface.Molecular microbiology · 2010Article
- Clinical relevance and diversity of two homologous genes encoding glycosyltransferases in Helicobacter pylori.Journal of clinical microbiology · 2010Article
- Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice.The Journal of experimental medicine · 2009Article
- Helicobacter pylori's unconventional role in health and disease.PLoS pathogens · 2009Review
- Article
- Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases.PloS one · 2008Article
- Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2006Article
- Helicobacter pylori phase variation, immune modulation and gastric autoimmunity.Nature reviews. Microbiology · 2006Review
- Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN.The Journal of experimental medicine · 2004Article
- Helicobacter pylori persistence: biology and disease.The Journal of clinical investigation · 2004Review
- Article
- Helicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/HeJ mice.Infection and immunity · 2002Article
- Dynamics of bacterial phenotype selection in a colonized host.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Phenotypic variation of Helicobacter pylori isolates from geographically distinct regions detected by lectin typing.Journal of clinical microbiology · 2002Article
- Helicobacter pylori genetic diversity and risk of human disease.The Journal of clinical investigation · 2001Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsLewis antigens occur in human gastric epithelium and in Helicobacter pylori lipopolysaccharide; their expression is polymorphic in both. Autoimmune mechanisms induced by bacterial Lewis expression have been proposed to cause gastritis. The aim of this study was to examine the relationship between bacterial and host gastric Lewis expression, as determined by the erythrocyte Lewis(a/b) phenotype, and between gastric histopathology and bacterial Lewis expression.
methodsH. pylori Lewis expression was determined by enzyme immunoassays, erythrocyte Lewis phenotype was assessed by agglutination tests, and gastric histopathology was scored blindly.
resultsThe host Lewis phenotype was (a+b-) in 15, (a-b+) in 34, and (a-b-) in 17 patients, therefore expressing Lewis x, y, or neither as their major gastric epithelial Lewis type 2 antigen. H. pylori from patients with Lewis(a+b-) expressed Lewis x more than y (1147 +/- 143 vs. 467 +/- 128 optical density units [ODU]; P = 0.006), isolates from patients with Lewis(a-b+) expressed Lewis x less than y (359 +/- 81 vs. 838 +/- 96 ODU; P = 0.0001), and isolates from Lewis(a-b-) patients expressed Lewis x and y approximately equally. Gastritis was unrelated to H. pylori Lewis expression.
conclusionsIn mimicking host gastric epithelium, H. pylori cells not only express Lewis x and y, but the relative proportion of expression corresponds to the host Lewis phenotype, suggesting selection for host-adapted organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.