ArticleNucleic acids research1997
p53-mediated DNA renaturation can mimic strand exchange.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Chromosome instability and deregulated proliferation: an unavoidable duo.Cellular and molecular life sciences : CMLS · 2012Review
- Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Zinc finger as distance determinant in the flexible linker of intron endonuclease I-TevI.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation.Oncogene · 2002Article
- Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53.Oncogene · 2000Article
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Authors and funding
4 authors.
Funding
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Abstract
The process of strand exchange is considered to be the hallmark of DNA recombination. Proteins known to carry out such exchange are believed to operate via one or the other of two mechanisms. RecA-like proteins promote the formation of a three-stranded or triplex synaptic intermediate in which strand exchange occurs, whereas other proteins would allow the coordinated exonucleolytic degradation of one strand in the duplex DNA and its replacement by an invading strand of similar sequence and polarity. In view of properties ascribed to it, we have attempted to determine whether p53 belongs to one or the other of these groups of proteins. The in vitro assay used relies on a double-stranded (ds) oligonucleotide (oligo 1+2) and a single-stranded (ss) oligonucleotide (oligo 3), part of which is complementary to oligo 1. The data collected suggest that, under the conditions of the assay, oligo 1+2 undergoes partial denaturation; p53 then catalyzes renaturation of oligo 1 with oligo 3, rather than true strand exchange. Since p53 is not known for being able to 'melt' DNA, it would seem unlikely that this protein would effect strand exchange in vivo without assistance from another, denaturing, protein.
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