ReviewNucleic acids research1997
Dynamics of potentiation and activation: GAGA factor and its role in heat shock gene regulation.
Review in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 110 citations in OpenAlex.
- Polycomb Recruiters Inside and Outside of the Repressed Domains.International journal of molecular sciences · 2023Review
- GAGA factor: a multifunctional pioneering chromatin protein.Cellular and molecular life sciences : CMLS · 2021Review
- Electromagnetic Field Seems to Not Influence Transcription via CTCT Motif in Three Plant Promoters.Frontiers in plant science · 2017Article
- GAGA factor, a positive regulator of global gene expression, modulates transcriptional pausing and organization of upstream nucleosomes.Epigenetics & chromatin · 2016Article
- Zelda is differentially required for chromatin accessibility, transcription factor binding, and gene expression in the early Drosophila embryo.Genome research · 2015Article
- Article
- Enforcing the pause: transcription factor Sp3 limits productive elongation by RNA polymerase II.Cell cycle (Georgetown, Tex.) · 2013Article
- Review
- Drosophila heat shock system as a general model to investigate transcriptional regulation.Cold Spring Harbor symposia on quantitative biology · 2010Review
- A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis.Arthritis research & therapy · 2010Article
- Promoter elements associated with RNA Pol II stalling in the Drosophila embryo.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Amyloidogenesis of natively unfolded proteins.Current Alzheimer research · 2008Review
- Increased myosin light chain kinase expression in hypertension: Regulation by serum response factor via an insertion mutation in the promoter.Molecular biology of the cell · 2006Article
- Identification of several cytoplasmic HSP70 genes from the Mediterranean mussel (Mytilus galloprovincialis) and their long-term evolution in Mollusca and Metazoa.Journal of molecular evolution · 2006Article
- Identification in vivo of different rate-limiting steps associated with transcriptional activators in the presence and absence of a GAGA element.Molecular and cellular biology · 2005Article
- ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons.Molecular and cellular biology · 2005Article
- dSAP18 and dHDAC1 contribute to the functional regulation of the Drosophila Fab-7 element.Nucleic acids research · 2005Article
- The enhancer-blocking activity of the Fab-7 boundary from the Drosophila bithorax complex requires GAGA-factor-binding sites.Genetics · 2004Article
- The cauliflower mosaic virus 35S promoter extends into the transcribed region.Journal of virology · 2004Article
- Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
GAGA factor (GAF) binds to specific DNA sequences and participates in a complex spectrum of chromosomal activities. Products of the Trithorax-like locus (Trl), which encodes multiple GAF isoforms, are required for homeotic gene expression and are essential for Drosophila development. While homozygous null mutations in Trl are lethal, heterozygotes display enhanced position effect variegation (PEV) indicative of the broad role of GAF in chromatin architecture and its positive role in gene expression.The distribution of GAF on chromosomes is complex, as it is associated with hundreds of chromosomal loci in euchromatin of salivary gland polytene chromosomes, however, it also displays a strong association with pericentric heterochromatin in diploid cells, where it appears to have roles in chromosome condensation and segregation. At higher resolution GAF binding sites have been identified in the regulatory regions of many genes. In some cases, the positive role of GAF in gene expression has been examined in detail using a variety of genetic, biochemical, and cytological approaches. Here we review what is currently known of GAF and, in the context of the heat shock genes of Drosophila, we examine the effects of GAF on multiple steps in gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.