ArticleThe EMBO journal1997
Cleavage of rabaptin-5 blocks endosome fusion during apoptosis.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer's disease.Journal of neuroinflammation · 2025Article
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- Caspase-mediated proteolysis of the sorting nexin 2 disrupts retromer assembly and potentiates Met/hepatocyte growth factor receptor signaling.Cell death discovery · 2017Article
- Hepatitis C virus promotes virion secretion through cleavage of the Rab7 adaptor protein RILP.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- ITSN2L Interacts with and Negatively Regulates RABEP1.International journal of molecular sciences · 2015Article
- Bcl-xL regulates CD1d-mediated antigen presentation to NKT cells by altering CD1d trafficking through the endocytic pathway.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster.Developmental biology · 2014Article
- Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis.Cell death & disease · 2010Article
- Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.Developmental cell · 2010Article
- Article
- Pro-apoptotic activity of imidazole derivatives mediated by up-regulation of Bax and activation of CAD in Ehrlich Ascites Tumor cells.Investigational new drugs · 2007Article
- Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery.Journal of virology · 2007Article
- Neurocrescin is specifically cleaved after the sequence DESD in a caspase-3-independent manner.Cellular and molecular neurobiology · 2004Article
- Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex.The EMBO journal · 2003Article
- Many cuts to ruin: a comprehensive update of caspase substrates.Cell death and differentiation · 2003Review
- Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex.Molecular biology of the cell · 2001Article
- Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150(Glued) stops dynein-dependent membrane motility.The Journal of cell biology · 2001Article
- Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription.Oncogene · 2000Article
- Activation of caspase 3 during Legionella pneumophila-induced apoptosis.Infection and immunity · 1999Article
- The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer.The Biochemical journal · 1999Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells undergoing apoptosis exhibit striking changes in membrane organization, including plasma membrane blebbing and invagination, vacuolation and fragmentation of organelles, and alterations in the surface expression of receptors. The underlying mechanisms for these changes are unknown, though alterations in vesicular fusion are likely to play a role. Using a cell-free system based on Xenopus laevis egg extracts we have found that endosome fusion is blocked during apoptosis. Inhibition of fusion is prevented by Bcl-2 or Bcl-xL, two negative regulators of apoptosis, or by specific inhibitors of members of the caspase family of apoptotic proteases. Selective cleavage of Rabaptin-5, an essential and rate-limiting component of endosome fusion, is responsible for the loss of fusion activity. Cleavage of Rabaptin-5 also occurs in cellular models for apoptosis. These results suggest that inactivation of Rabaptin-5 and inhibition of vesicle transport lead to fragmentation of endosomes and inhibition of the endocytic pathway during the execution phase of apoptosis. We propose that parallel changes to other membrane transport pathways would give rise to general membrane fragmentation in apoptotic cells. These changes are likely to play an important role in the generation of apoptotic bodies and their recognition by phagocytosing cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.