ArticleInfection and immunity1997
Priming of neutrophil respiratory burst activity by lipopolysaccharide from Burkholderia cepacia.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HTMolecules (Basel, Switzerland) · 2024Article
- The Prolyl Isomerase Pin1 Controls Lipopolysaccharide-Induced Priming of NADPH Oxidase in Human Neutrophils.Frontiers in immunology · 2019Article
- Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation.PLoS pathogens · 2017Article
- A Pseudomonas aeruginosa hepta-acylated lipid A variant associated with cystic fibrosis selectively activates human neutrophils.Journal of leukocyte biology · 2016Article
- Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages.Journal of leukocyte biology · 2011Article
- Organisms isolated from adults with cystic fibrosis.Annals of clinical microbiology and antimicrobials · 2004Article
- Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide.Infection and immunity · 2004Article
- Attenuated virulence of a Burkholderia cepacia type III secretion mutant in a murine model of infection.Infection and immunity · 2003Article
- Phagocyte NADPH oxidase, but not inducible nitric oxide synthase, is essential for early control of Burkholderia cepacia and chromobacterium violaceum infection in mice.Infection and immunity · 2003Article
- State of the art: why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection?Respiratory research · 2003Review
- Differential persistence among genomovars of the Burkholderia cepacia complex in a murine model of pulmonary infection.Infection and immunity · 2002Article
- Enhanced susceptibility to pulmonary infection with Burkholderia cepacia in Cftr(-/-) mice.Infection and immunity · 2001Article
- Lipopolysaccharide of Burkholderia cepacia and its unique character to stimulate murine macrophages with relative lack of interleukin-1beta-inducing ability.Infection and immunity · 2001Article
- Detection of heme-binding proteins in epidemic strains of Burkholderia cepacia.Clinical and diagnostic laboratory immunology · 2001Article
- Outbreak of subclinical mastitis in a flock of dairy sheep associated with Burkholderia cepacia complex infection.Journal of clinical microbiology · 2001Article
- Cable-piliated Burkholderia cepacia binds to cytokeratin 13 of epithelial cells.Infection and immunity · 2000Article
- A murine model for infection with Burkholderia cepacia with sustained persistence in the spleen.Infection and immunity · 1999Article
- A melanin pigment purified from an epidemic strain of Burkholderia cepacia attenuates monocyte respiratory burst activity by scavenging superoxide anion.Infection and immunity · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophil activation may play an important role in the pathogenesis of respiratory disease in Burkholderia cepacia-colonized cystic fibrosis (CF) patients. As bacterial lipopolysaccharides (LPS) are potent immunostimulatory molecules, we investigated the role of B. cepacia LPS in neutrophil activation processes. LPS extracted from a highly transmissible and virulent strain of B. cepacia (J2315) was found to increase neutrophil surface expression of the beta2 integrin, complement receptor 3, and to prime neutrophil respiratory burst responses to the neutrophil-activating agent fMet-Leu-Phe. By contrast, LPS extracted from a nonmucoid Pseudomonas aeruginosa strain isolated from a patient with CF showed little or no priming activity. As B. cepacia is currently being developed as a biocontrol agent for large-scale agricultural release, we compared LPS molecules from a range of bacterial strains for their proinflammatory ability. Priming activity was demonstrated in LPS extracts from all B. cepacia strains tested, with one environmental strain, J2552, showing the highest activity. These findings indicate (i) that B. cepacia LPS may contribute to the inflammatory nature of B. cepacia infection in CF patients, both by promoting increased neutrophil recruitment and by priming neutrophil respiratory burst responses, and (ii) that environmental strains of B. cepacia may have considerable inflammatory potential in susceptible individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.