Trial reportJournal of clinical microbiology1997
Proficiency testing of clinical microbiology laboratories using modified decontamination procedures for detection of nontuberculous mycobacteria in sputum samples from cystic fibrosis patients. The Nontuberculous Mycobacteria in Cystic Fibrosis Study Group.
Trial report in Journal of clinical microbiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00004296 (Multicenter Study of Nontuberculous Mycobacteria in Cystic Fibrosis Patients), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Study of Nontuberculous Mycobacteria in Cystic Fibrosis Patients
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline
- Pathogenicity and virulence ofVirulence · 2025Review
- Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway.Tuberculosis (Edinburgh, Scotland) · 2023Article
- Article
- Article
- Prevalence of rifampicin resistance tuberculosis among HIV/TB coinfected patients in Benue State, Nigeria.The Pan African medical journal · 2021Article
- Surgery in nontuberculous mycobacteria pulmonary disease.Breathe (Sheffield, England) · 2018Review
- Rapid detection and immune characterization of Mycobacterium abscessus infection in cystic fibrosis patients.PloS one · 2015Article
- Prevalence and drug resistance of mycobacteria in Turkish cystic fibrosis patients.Annals of clinical microbiology and antimicrobials · 2014Article
- Detection of rapidly growing mycobacteria in routine cultures of samples from patients with cystic fibrosis.Journal of clinical microbiology · 2011Article
- Chronic Mycobacterium abscessus infection and lung function decline in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2010Article
- Molecular epidemiology of Mycobacterium abscessus, with focus on cystic fibrosis.Journal of clinical microbiology · 2007Article
- Value of the chlorhexidine decontamination method for recovery of nontuberculous mycobacteria from sputum samples of patients with cystic fibrosis.Journal of clinical microbiology · 2006Article
- Non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation.Thorax · 2006Article
- Age-related prevalence and distribution of nontuberculous mycobacterial species among patients with cystic fibrosis.Journal of clinical microbiology · 2005Article
- Mycobacterium abscessus and children with cystic fibrosis.Emerging infectious diseases · 2003Article
- Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis.Journal of clinical microbiology · 2001Article
- Recovery of mycobacteria from patients with cystic fibrosis.Journal of clinical microbiology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An improved decontamination method has been demonstrated to reduce overgrowth of mycobacterial media by Pseudomonas aeruginosa and allow the successful recovery of nontuberculous mycobacteria (NTM) from cystic fibrosis (CF) patients. Twenty microbiology laboratories participating in a multicenter investigation designed to determine the significance of NTM in CF patients were required to demonstrate proficiency in the incorporation of this improved method; this was accomplished by successful decontamination and culture workup of a panel of simulated sputum samples seeded with P. aeruginosa and various NTM. All laboratories successfully recovered NTM from samples with acid-fast bacillus (AFB) smear scores of 3+/4+ (i.e., 2 to 18 or > 18 organisms/field). Low-inoculum samples (1+/2+ AFB smears [2 to 18 organisms in 100 or 10 fields]) were problematic in that processed specimens were often smear and/or culture negative.
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