ArticleJournal of clinical microbiology1997
Determination of the etiology of presumptive feline leprosy by 16S rRNA gene analysis.
Article in Journal of clinical microbiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Article
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- Idiopathic sterile pyogranuloma in three domestic cats.The Journal of small animal practice · 2020Article
- Insights from the Genome Sequence ofmBio · 2017Article
- Feline leprosy due to Candidatus 'Mycobacterium lepraefelis': Further clinical and molecular characterisation of eight previously reported cases and an additional 30 cases.Journal of feline medicine and surgery · 2017Observational
- Leprosy - we've much left to learn, but are looking to squirrels, cows and cats for insights.Journal of feline medicine and surgery · 2017Article
- Systemic mycobacteriosis caused by 'Mycobacterium avium subspecies hominissuis' in a 14-month-old Japanese black beef steer.The Journal of veterinary medical science · 2017Article
- Feline leprosy due to Mycobacterium lepraemurium.Journal of feline medicine and surgery · 2017Article
- History and mysteries of leprosy.Journal of feline medicine and surgery · 2017Article
- Feline leprosy due to Candidatus 'Mycobacterium tarwinense':Further clinical and molecular characterisation of 15 previously reported cases and an additional 27 casesJournal of feline medicine and surgery · 2017Article
- [Colonization of Porphyromonas endodontalis in primary and secondary endodontic infections].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2015Article
- Localised Mycobacterium ulcerans infection in a cat in Australia.Journal of feline medicine and surgery · 2008Article
- Molecular characterization of a novel fastidious mycobacterium causing lepromatous lesions of the skin, subcutis, cornea, and conjunctiva of cats living in Victoria, Australia.Journal of clinical microbiology · 2008Article
- Mycobacterium avium in the postgenomic era.Clinical microbiology reviews · 2007Review
- Disseminated Mycobacterium avium infection in young cats: overrepresentation of Abyssinian cats.Journal of feline medicine and surgery · 2006Article
- PCR studies of feline leprosy cases.Journal of feline medicine and surgery · 2004Article
- Analysis of Mycobacterium species for the presence of a macrolide toxin, mycolactone.Infection and immunity · 2004Article
- Opportunistic mycobacterial granuloma in a cat associated with a member of the Mycobacterium terrae complex.Journal of feline medicine and surgery · 2003Article
- Histologic and genotypic characterization of a novel Mycobacterium species found in three cats.Journal of clinical microbiology · 2002Article
- Feline leprosy: two different clinical syndromes.Journal of feline medicine and surgery · 2002Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PCR-amplified 16S rRNA gene sequences were obtained directly from tissue specimens from eight cats with presumptive feline leprosy. Acid-fast bacilli were observed in sections from all eight specimens, but culture for mycobacteria was successful for one specimen only. Analysis of the V2 variable region of each 16S rRNA PCR product identified a sequence with 100% nucleotide identity to the sequences of Mycobacterium lepraemurium, Mycobacterium avium, and Mycobacterium paratuberculosis in four of the specimens from cats with feline leprosy. Separate M. paratuberculosis- and M. avium-specific PCR amplifications of the four specimens were negative, thus substantiating the identification of M. lepraemurium in these specimens from cats with feline leprosy. Further sequence analysis of the V3 variable region of one of the four specimens provided conclusive evidence of the presence of M. lepraemurium. This is the first report of the definitive identification of M. lepraemurium in cats with feline leprosy by molecular biology-based analyses. M. avium, which is rarely reported in cats, and Mycobacterium chitae, a reported nonpathogenic, rapidly growing mycobacterial species found in the environment, were identified in the specimen from which acid-fast bacilli were cultured. Two of the specimens from cats were infected with a potentially novel species of mycobacteria which had a 16S rRNA gene sequence sharing the closest nucleotide sequence identity with that of Mycobacterium malmoense. Molecular biology-based analyses provided for the accurate and rapid diagnosis of mycobacterial infections in cats and circumvented the problems of culture and misdiagnosis of feline leprosy associated with traditional methods.
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