ArticleThe Journal of experimental medicine1997
Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon gamma: a possible initiating role of B cells.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 84 citations in OpenAlex.
- A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance.Annals of the New York Academy of Sciences · 2015Review
- β-arrestin 2 inhibits proinflammatory chemokine production and attenuates contact allergic inflammation in the skin.The Journal of investigative dermatology · 2014Article
- Disruption of the complement anaphylatoxin receptor C5L2 exacerbates inflammation in allergic contact dermatitis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The lymphocyte immunophenotypical pattern in chronic lymphocytic leukemia associated with hepatitis viral infections.Journal of medicine and life · 2011Article
- The Vaccinia virus complement control protein modulates adaptive immune responses during infection.Journal of virology · 2011Article
- CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli.Infection and immunity · 2009Article
- Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation.American journal of respiratory and critical care medicine · 2008Article
- Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance.The Journal of clinical investigation · 2007Article
- Enhanced apoptosis of peripheral CD5-negative B lymphocytes from chronically hepatitis C virus-infected patients: reversal after antiviral treatment.Journal of virology · 2004Article
- Article
- Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity.The Journal of experimental medicine · 2003Article
- Up-regulation of C5a receptor expression and function on human monocyte derived dendritic cells by prostaglandin E2.Immunology · 2003Article
- Antiviral treatment down-regulates peripheral B-cell CD81 expression and CD5 expansion in chronic hepatitis C virus infection.Journal of virology · 2003Article
- Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells.Nature medicine · 2003Article
- B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity.The Journal of experimental medicine · 2002Article
- Peripheral B-cell CD5 expansion and CD81 overexpression and their association with disease severity and autoimmune markers in chronic hepatitis C virus infection.Clinical and experimental immunology · 2002Article
- Article
- Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2.The Journal of experimental medicine · 2000Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Complement (C) is an important component of innate immunity, and was also shown recently to participate in induction of acquired B cell humoral immunity. In this study, we present evidence that C also participates in acquired T cell immunity. We found that C was involved in early events of the efferent elicitation phase of contact sensitivity (CS), and delayed-type hypersensitivity (DTH). Thus, CS and DTH were inhibited by administration of a C-blocker, soluble recombinant C receptor-1 (sCR1), when given 30 min before, but not 3 h after local antigen challenge. Among C components, local C5 were thought crucial to elicitation of CS, since local administration of anti-C5 monoclonal antibodies or locally injected C-depleting cobra venom factor also inhibited CS and DTH. These findings were consistent with our previous finding of the importance of C5 for CS elicitation, using congenitally C5-deficient mice. To dissect the mechanism of C dependence in CS, we demonstrated that locally increased early macrophage chemotactic activity (probably C5a) in evolving CS skin extracts, as well as late elaboration of IFN-gamma, were both inhibited by anti-C treatment. In addition, histological analysis showed that leukocyte recruitment into CS ear sites was similarly C-dependent. Furthermore, an initiating role of B cell-derived C-fixing immunoglobulin was suggested by demonstration of impaired CS responses in B cell-deficient mice. In summary, these results suggest that C was activated locally, perhaps via a B cell product, in an important early component of the stepwise events necessary to elicit CS, leading to local production of C5-dependent macrophage chemotactic activity and later IFN-gamma, and subsequently leading to cell infiltration, for development of T cell-dependent CS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.