ArticleThe Journal of experimental medicine1997
Ontogeny of the immune system: gamma/delta and alpha/beta T cells migrate from thymus to the periphery in alternating waves.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Phenotypic Remodeling of γδ T Cells in Non-Eosinophilic Chronic Rhinosinusitis with Nasal Polyposis.Medicina (Kaunas, Lithuania) · 2025Article
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- Characterization of the chicken T cell receptor γ repertoire by high-throughput sequencing.BMC genomics · 2021Article
- A Novel Recombinant Newcastle Disease Vaccine Improves Post-Vaccines · 2021Article
- Innate Lymphocytes in Psoriasis.Frontiers in immunology · 2020Review
- Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal iNKT cells.Life science alliance · 2019Article
- Article
- IL-17A-producing resident memory γδ T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- CD4+CD25+ Regulatory T cell ontogeny and preferential migration to the cecal tonsils in chickens.PloS one · 2012Article
- Thymic T cell development and progenitor localization depend on CCR7.The Journal of experimental medicine · 2004Article
- Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice.The Journal of experimental medicine · 2003Article
- RSV bronchiolitis, gammadelta T cells and asthma: are they linked?Clinical and experimental immunology · 2003Article
- The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice.The Journal of experimental medicine · 2001Article
- L-selectin expression on thymic emigrants defines two distinct tissue-migration pathways.Immunology · 1999Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The embryonic thymus is colonized by the influx of hemopoietic progenitors in waves. To characterize the T cell progeny of the initial colonization waves, we used intravenous adoptive transfer of bone marrow progenitors into congenic embryos. The experiments were performed in birds because intravenous cell infusions can be performed more efficiently in avian than in mammalian embryos. Progenitor cells, which entered the vascularized thymus via interlobular venules in the capsular region and capillaries located at the corticomedullary junction, homed to the outer cortex to begin thymocyte differentiation. The kinetics of differentiation and emigration of the T cell progeny were analyzed for the first three waves of progenitors. Each progenitor wave gave rise to gamma/delta T cells 3 d earlier than alpha/beta T cells. Although the flow of T cell migration from the thymus was uninterrupted, distinct colonization and differentiation kinetics defined three successive waves of gamma/delta and alpha/beta T cells that depart sequentially the thymus en route to the periphery. Each wave of precursors rearranged all three TCR Vgamma gene families, but displayed a variable repertoire. The data indicate a complex pattern of repertoire diversification by the progeny of founder thymocyte progenitors.
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