ArticleThe Journal of clinical investigation1997
Nitric oxide mediates murine cytomegalovirus-associated pneumonitis in lungs that are free of the virus.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 40 citations in OpenAlex.
- Utility of NO and HNitric oxide : biology and chemistry · 2022Review
- Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung Injury.PloS one · 2015Article
- Antiviral prevention of sepsis induced cytomegalovirus reactivation in immunocompetent mice.Antiviral research · 2010Article
- Nitric oxide in dengue and dengue haemorrhagic fever: necessity or nuisance?FEMS immunology and medical microbiology · 2009Review
- Role of epithelial nitric oxide in airway viral infection.Free radical biology & medicine · 2006Review
- Down-regulation of inducible nitric oxide synthase by lysophosphatidic acid in human respiratory epithelial cells.Molecular and cellular biochemistry · 2004Article
- Murine model of interstitial cytomegalovirus pneumonia in syngeneic bone marrow transplantation: persistence of protective pulmonary CD8-T-cell infiltrates after clearance of acute infection.Journal of virology · 2000Article
- Association of cytomegalovirus interstitial pneumonitis with HLA-type following allogeneic bone marrow transplantation.Bone marrow transplantation · 2000Article
- Rapid interferon gamma-dependent clearance of influenza A virus and protection from consolidating pneumonitis in nitric oxide synthase 2-deficient mice.The Journal of experimental medicine · 1998Article
- Resistance to murine hepatitis virus strain 3 is dependent on production of nitric oxide.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
4 wk after intraperitoneal inoculation of 0.2 LD50 (50% lethal dose) of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable in the salivary glands, but not in the lungs or other organs. When the T cells of these mice were activated in vivo by a single injection of anti-CD3 monoclonal antibody, interstitial pneumonitis was induced in the lungs that were free of the virus with an excessive production of the cytokines. In the lungs of such mice persistently infected with MCMV, the mRNA of the cytokines such as IL-2, IL-6, TNF-alpha, and IFN-gamma were abundantly expressed 3 h after the anti-CD3 injection, and the elevated levels continued thereafter. A marked expression of inducible nitric oxide synthetase (iNOS) was then noted in the lungs, suggesting that such cytokines as TNF-alpha and IFN-gamma may have induced iNOS. Although the increase in NO formation was demonstrated by the significant elevation of the serum levels of nitrite and nitrate, the interstitial pneumonitis was not associated with either increased superoxide formation or peroxynitrite-induced tyrosine nitration. Nevertheless, the administration of an NO antagonist also alleviated the interstitial pneumonitis provoked by anti-CD3 mAb. Based on these findings, it was concluded that MCMV-associated pneumonitis is mediated by a molecule of cytokine-induced NO other than peroxynitrite.
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