ArticleThe Journal of clinical investigation1997
Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 227 citations in OpenAlex.
- Maternal fasting during early gestation induces epigenetic alterations and schizophrenia-related phenotypes.Molecular psychiatry · 2026Article
- Maternal low protein diet and fetal programming of lean type 2 diabetes.World journal of diabetes · 2022Review
- Breastfeeding on childhood obesity in children were large-for-gestational age: retrospective study from birth to 4 years.Scientific reports · 2022Article
- Epigenetics andFrontiers in genetics · 2019Review
- The Microbiological Memory, an Epigenetic Regulator Governing the Balance Between Good Health and Metabolic Disorders.Frontiers in microbiology · 2018Article
- Effects of stress during pregnancy on hepatic glucogenic capacity in rat dams and their fetuses.Physiological reports · 2017Article
- Developmental programming: State-of-the-science and future directions-Summary from a Pennington Biomedical symposium.Obesity (Silver Spring, Md.) · 2016Review
- Regulation of liver development: implications for liver biology across the lifespan.Journal of molecular endocrinology · 2016Review
- Diet, behavior and immunity across the lifespan.Neuroscience and biobehavioral reviews · 2015Review
- Maternal cholestasis during pregnancy programs metabolic disease in offspring.The Journal of clinical investigation · 2013Article
- Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin.PloS one · 2013Article
- Glucose intolerance and lipid metabolic adaptations in response to intrauterine and postnatal calorie restriction in male adult rats.Endocrinology · 2013Article
- Intergenerational effects of maternal birth season on offspring size in rural Gambia.Proceedings. Biological sciences · 2012Article
- Developmental origins of diabetes: The role of oxidative stress.Best practice & research. Clinical endocrinology & metabolism · 2012Article
- Fetal programming and metabolic syndrome.Annual review of physiology · 2012Review
- Fetal origin of vascular aging.Indian journal of endocrinology and metabolism · 2011Article
- Maternal protein restriction elevates cholesterol in adult rat offspring due to repressive changes in histone modifications at the cholesterol 7alpha-hydroxylase promoter.Molecular endocrinology (Baltimore, Md.) · 2011Article
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- Inbuilt mechanisms for overcoming functional problems inherent in hepatic microlobular structure.Computational and mathematical methods in medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal protein restriction is a model of fetal programming of adult glucose intolerance. Perfused livers of 48-h- starved adult offspring of rat dams fed 8% protein diets during pregnancy and lactation produced more glucose from 6 mM lactate than did control livers from rats whose dams were fed 20% protein. In control livers, a mean of 24% of the glucose formed from lactate in the periportal region of the lobule was taken up by the most distal perivenous cells; this distal perivenous uptake was greatly diminished in maternal low protein (MLP) livers, accounting for a major fraction of the increased glucose output of MLP livers. In control livers, the distal perivenous cells contained 40% of the total glucokinase of the liver; this perivenous concentration of glucokinase was greatly reduced in MLP livers. Intralobular distribution of phosphenolpyruvate carboxykinase was unaltered, though overall increased activity could have contributed to the elevated glucose output. Hepatic lobular volume in MLP livers was twice that in control livers, indicating that MLP livers had half the normal number of lobules. Fetal programming of adult glucose metabolism may operate partly through structural alterations and changes in glucokinase expression in the immediate perivenous region.
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