ArticleThe Journal of clinical investigation1997
Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Low-dose theophylline in addition to ICS therapy in COPD patients: A systematic review and meta-analysis.PloS one · 2021Pooled it
- A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2002Trial
- Potent Anti-Inflammatory Effects of Tetracyclines on Human Eosinophils.Frontiers in allergy · 2021Article
- Exploring inflammatory disease drug effects on neutrophil function.The Analyst · 2014Article
- Concurrent oral and inhalation drug delivery using a dual formulation system: the use of oral theophylline carrier with combined inhalable budesonide and terbutaline.Drug delivery and translational research · 2014Article
- Mitochondria in the center of human eosinophil apoptosis and survival.International journal of molecular sciences · 2014Review
- Regulation of spontaneous eosinophil apoptosis-a neglected area of importance.Journal of cell death · 2014Review
- Eosinophils in the lung - modulating apoptosis and efferocytosis in airway inflammation.Frontiers in immunology · 2014Review
- Idiopathic systemic capillary leak syndrome preceding diagnosis of infiltrating lobular carcinoma of the breast with quiescence during neoadjuvant chemotherapy.Mayo Clinic proceedings · 2011Article
- Theophylline.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Article
- Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people: recommendations for prescribing.Drugs & aging · 2008Review
- Theophylline treatment may adversely affect the anoxia-induced erythropoietic response without suppressing erythropoietin production.European journal of clinical pharmacology · 2003Article
- Decreased neutrophil apoptosis in tracheal fluids of preterm infants at risk of chronic lung disease.Archives of disease in childhood. Fetal and neonatal edition · 2003Article
- Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma.British journal of pharmacology · 2003Article
- Review
- New clinical applications of xanthine derivatives: modulatory actions on leukocyte survival and function.International journal of hematology · 2001Review
- The role of adenosine receptors in the action of theophylline on human peripheral blood mononuclear cells from healthy and asthmatic subjects.British journal of pharmacology · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Theophylline, in addition to its bronchodilator effect, is reported to have an antiinflammatory action that may account for its clinical effectiveness in the reduction of inflammatory cells in the airway. In bronchial asthma, such inflammatory cytokines as GM-CSF and IL-5 are upregulated and have been proposed to cause granulocyte infiltration (neutrophils and eosinophils) in the airway by inhibition of granulocyte apoptosis. We examined the abilities of theophylline to counteract the prolongation of human granulocyte survival caused by cytokines. Theophylline was shown to shorten granulocyte survival in a dose-dependent manner. Upon incubation with a therapeutical concentration of theophylline (0.1 mM; 18 microg/ml), percentages of GM-CSF (10 ng/ml)-induced delayed apoptosis increased from 18+/-2% to 38+/-3% (p < 0.02) in neutrophils and from 21+/-2% to 35+/-2% (p < 0.02; 24-h incubation) in eosinophils. The percentage of IL-5 (5 ng/ml)-induced delayed eosinophil apoptosis also increased from 22+/-4% to 33+/-2% (P < 0. 05). In contrast, cyclic AMP (cAMP)-increasing agents (3-isobutylmethylxanthine, dibutyryl cAMP, and rolipram) inhibited granulocyte apoptosis in the control and anti-Fas antibody-treated cells. In eosinophils, the expression of bcl-2 protein decreased after incubation with theophylline. These findings suggest that theophylline accelerates granulocyte apoptosis, which may play an essential role in inflammation, and controls granulocyte longevity regardless of the elevation of intracellular cAMP levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.