ArticleThe EMBO journal1997
Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Article
- Nonsense mutation-dependent reinitiation of translation in mammalian cells.Nucleic acids research · 2019Article
- Mutant p53 protein expression and antioxidant status deficiency in breast cancer.EXCLI journal · 2014Article
- Uncovering the basis of ATP hydrolysis activity in purified human p53 protein: a reinvestigation.PloS one · 2014Article
- The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity.The EMBO journal · 2006Article
- The C terminus of p53 family proteins is a cell fate determinant.Molecular and cellular biology · 2005Article
- p53 protein variants: structural and functional similarities with p63 and p73 isoforms.Oncogene · 2004Review
- Several regions of p53 are involved in repression of RNA polymerase III transcription.Oncogene · 2002Article
- Doxorubicin and octreotide induce a 40 kDa breakdown product of p53 in human hepatoma and tumoral colon cell lines.The Biochemical journal · 2002Article
- p53 binds the nuclear matrix in normal cells: binding involves the proline-rich domain of p53 and increases following genotoxic stress.Oncogene · 2001Article
- Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression.The Journal of cell biology · 2001Article
- p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53.Oncogene · 2000Article
- Article
- Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation.Oncogene · 2000Article
- Review
- An ATP/ADP-dependent molecular switch regulates the stability of p53-DNA complexes.Molecular and cellular biology · 1999Article
- Dissociation of the recombination control and the sequence-specific transactivation function of P53.Oncogene · 1999Article
- Proteolytic cleavage of p53 mutants in response to mismatched DNA.British journal of cancer · 1999Article
- Activation of caspases and p53 by bovine herpesvirus 1 infection results in programmed cell death and efficient virus release.Journal of virology · 1999Article
- In vitro evolution of thermostable p53 variants.Protein science : a publication of the Protein Society · 1999Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p53 is able to recognize and bind sites of DNA damage and, in some way, damage to cellular DNA activates a p53 response leading to G1 arrest or apoptosis. We have previously shown that 'damaged DNA' induces N-terminal cleavage of p53 to generate p40(DeltaN) and p35 (core) protein products. We now show that the p35 product has protease activity and is able to cleave between residues 23 and 24 of full-length p53 to generate a novel product, p50(DeltaN23). This activity was inhibited by bestatin, an aminopeptidase inhibitor. Residues 23 and 24 lie within the mdm-2 binding domain of p53 and the possibility that p50(DeltaN23) may be resistant to feedback regulation by mdm-2 is discussed. Unexpectedly, interaction with ssDNA induced two further cleavage products of p53, generated by C-terminal cleavage and designated p50(DeltaC) and p40(DeltaC). In vivo generation of a C-terminal cleavage product of endogenous p53 similar in size to p50(DeltaC) correlated with up-regulation of p21 expression in ML-1 cells exposed to either adriamycin or cisplatin. The possible significance of the various p53 cleavage products in relation to the cellular response to DNA damage is discussed.
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