ArticleThe EMBO journal1997
Src and Ras are involved in separate pathways in epithelial cell scattering.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 139 citations in OpenAlex.
- Intrahepatic Cholangiocarcinoma With Sarcomatous Transformation: Demonstrating the Transition Zone.ACG case reports journal · 2024Article
- A novel anoikis-related gene prognostic signature and its correlation with the immune microenvironment in colorectal cancer.Frontiers in genetics · 2023Article
- PTRH2: an adhesion regulated molecular switch at the nexus of life, death, and differentiation.Cell death discovery · 2020Review
- Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis.Cancers · 2020Review
- c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression.Nature communications · 2019Article
- Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement.Journal of cell science · 2019Article
- Adherens Junctions on the Move-Membrane Trafficking of E-Cadherin.Cold Spring Harbor perspectives in biology · 2017Review
- A huge adenosquamous carcinoma of the pancreas with sarcomatoid change: an unusual case report.World journal of gastroenterology · 2014Article
- Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferation.Development (Cambridge, England) · 2012Article
- Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis.The Journal of biological chemistry · 2012Article
- Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer.American journal of cancer research · 2012Article
- The role of MAPK in drug-induced kidney injury.Journal of signal transduction · 2012Article
- Implication of stem cells in the biology and therapy of head and neck cancer.GMS current topics in otorhinolaryngology, head and neck surgery · 2011Article
- SRC: a century of science brought to the clinic.Neoplasia (New York, N.Y.) · 2010Review
- Numb regulates cell-cell adhesion and polarity in response to tyrosine kinase signalling.The EMBO journal · 2009Article
- Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530.Molecular oncology · 2009Article
- Lipocalin 2 promotes breast cancer progression.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells.Experimental & molecular medicine · 2009Article
- Transcriptional regulation of metastatic [Id]entity by KLF17.Genome biology · 2009Review
- Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer.PloS one · 2008Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
We have demonstrated previously that Src controls the epidermal growth factor (EGF)-induced dispersion of NBT-II carcinoma epithelial cells. Here we show that while only Src and Yes were expressed and activated by EGF, microinjected kinase-inactive mutants of Src (SrcK-) and Fyn (FynK-) were able to exert a dominant-negative effect on the scattering response. Both SH2 and SH3 domains of FynK- were required for inhibition of cell scattering. Expression of dominant-negative N17Ras also abrogated EGF-induced dispersion, showing that Ras is another regulator of cell dispersion. Expression of SrcK- did not alter EGF-evoked Shc tyrosine phosphorylation, Shc-Grb2 complex formation and MAPK activation, three elements of the Ras pathway. Furthermore, the expression of Jun-Fos and Slug rescued the block induced by N17Ras but not by SrcK-, showing that Src kinases and Ras operate in separate pathways. In addition, actinomycin D inhibition of RNA synthesis repressed the ability of the activated mutant L61Ras but not that of F527Src to induce epithelial cell scattering. Since tyrosine phosphorylation of cytoskeleton-associated proteins pp125FAK and cortactin were abolished in EGF-stimulated SrcK- cells, we concluded that, in contrast to Ras, Src kinases may control epithelial cell dispersion in the absence of gene expression and by directly regulating the organization of the cortical cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.