ArticleThe EMBO journal1997
Coordinated intercellular calcium waves induced by noradrenaline in rat hepatocytes: dual control by gap junction permeability and agonist.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 146 citations in OpenAlex.
- Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland.Journal of neurochemistry · 2019Article
- Role of intracellular CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Causality Analysis and Cell Network Modeling of Spatial Calcium Signaling Patterns in Liver Lobules.Frontiers in physiology · 2018Article
- Computational Modeling of Spatiotemporal Ca(2+) Signal Propagation Along Hepatocyte Cords.IEEE transactions on bio-medical engineering · 2016Article
- Mechanics regulates ATP-stimulated collective calcium response in fibroblast cells.Journal of the Royal Society, Interface · 2015Article
- Osteogenic gene transcription is regulated via gap junction-mediated cell-cell communication.Stem cells and development · 2015Article
- Calcium signaling in the liver.Comprehensive Physiology · 2013Review
- Intercellular Ca(2+) waves: mechanisms and function.Physiological reviews · 2012Review
- Calcium signalling and liver regeneration.International journal of hepatology · 2012Article
- Spatiotemporal characteristics of calcium dynamics in astrocytes.Chaos (Woodbury, N.Y.) · 2009Article
- Calcium influx mechanisms underlying calcium oscillations in rat hepatocytes.Hepatology (Baltimore, Md.) · 2008Article
- Connexin specificity of second messenger permeation: real numbers at last.The Journal of general physiology · 2008Article
- The spatial distribution of inositol 1,4,5-trisphosphate receptor isoforms shapes Ca2+ waves.The Journal of biological chemistry · 2007Article
- Quantitative characterization of biological liquids for third-harmonic generation microscopy.Biophysical journal · 2007Article
- Role of voltage-dependent modulation of store Ca2+ release in synchronization of Ca2+ oscillations.Biophysical journal · 2006Article
- Intercellular calcium signalling in cultured renal epithelia: a theoretical study of synchronization mode and pacemaker activity.European biophysics journal : EBJ · 2004Article
- Kinetics and mechanism of intercellular ice propagation in a micropatterned tissue construct.Biophysical journal · 2002Article
- Intercellular Ca2+ wave propagation through gap-junctional Ca2+ diffusion: a theoretical study.Biophysical journal · 2001Article
- Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia.The Journal of cell biology · 2000Article
- Model of intercellular calcium oscillations in hepatocytes: synchronization of heterogeneous cells.Biophysical journal · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium-mobilizing agonists induce intracellular Ca2+ concentration ([Ca2+]i) changes thought to trigger cellular responses. In connected cells, rises in [Ca2+]i can propagate from cell to cell as intercellular Ca2+ waves, the mechanisms of which are not elucidated. Using fura2-loaded rat hepatocytes, we studied the mechanisms controlling coordination and intercellular propagation of noradrenaline-induced Ca2+ signals. Gap junction blockade with 18 alpha-glycyrrhetinic acid resulted in a loss of coordination between connected cells. We found that second messengers and [Ca2+]i rises in one hepatocyte cannot trigger Ca2+ responses in connected cells, suggesting that diffusion across gap junctions, while required for coordination, is not sufficient by itself for the propagation of intercellular Ca2+ waves. In addition, our experiments revealed functional differences between noradrenaline-induced Ca2+ signals in connected hepatocytes. These results demonstrate that intercellular Ca2+ signals in multicellular systems of rat hepatocytes are propagated and highly organized through complex mechanisms involving at least three factors. First, gap junction coupling ensures coordination of [Ca2+]i oscillations between the different cells; second, the presence of hormone at each hepatocyte is required for cell-cell Ca2+ signal propagation; and third, functional differences between adjacent connected hepatocytes could allow a 'pacemaker-like' intercellular spread of Ca2+ waves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.