ArticleJournal of virology1997
Rabies virus infects mouse and human lymphocytes and induces apoptosis.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 101 citations in OpenAlex.
- Responsiveness of various reservoir species to oral rabies vaccination correlates with differences in vaccine uptake of mucosa associated lymphoid tissues.Scientific reports · 2020Article
- Article
- Enhanced transport of plant-produced rabies single-chain antibody-RVG peptide fusion protein across an in cellulo blood-brain barrier device.Plant biotechnology journal · 2017Article
- Impact of caspase-1/11, -3, -7, or IL-1Cell death discovery · 2017Article
- Phosphoprotein Gene Contributes to the Enhanced Apoptosis Induced by Wild-Type Rabies Virus GD-SH-01Frontiers in microbiology · 2017Article
- Wild-type rabies virus induces autophagy in human and mouse neuroblastoma cell lines.Autophagy · 2016Article
- Monocytes and B cells support active replication of Chandipura virus.BMC infectious diseases · 2016Article
- Subversion of the Immune Response by Rabies Virus.Viruses · 2016Review
- Systems Biomedicine of Rabies Delineates the Affected Signaling Pathways.Frontiers in microbiology · 2016Article
- Factors for early death in rabies- the bitter truth.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2015Article
- B cell infection and activation by rabies virus-based vaccines.Journal of virology · 2013Article
- Passive carriage of rabies virus by dendritic cells.SpringerPlus · 2013Article
- Immune clearance of attenuated rabies virus results in neuronal survival with altered gene expression.PLoS pathogens · 2012Article
- Apoptosis induced in vivo by new type gosling viral enteritis virus.Journal of veterinary science · 2011Article
- The type I interferon response bridles rabies virus infection and reduces pathogenicity.Journal of neurovirology · 2011Article
- Ambivalent role of the innate immune response in rabies virus pathogenesis.Journal of virology · 2011Article
- Role of apoptosis in rabies viral encephalitis: a comparative study in mice, canine, and human brain with a review of literature.Pathology research international · 2011Article
- Two overlapping domains of a lyssavirus matrix protein that acts on different cell death pathways.Journal of virology · 2010Article
- Molecular basis of neurovirulence of flury rabies virus vaccine strains: importance of the polymerase and the glycoprotein R333Q mutation.Journal of virology · 2010Article
- The cell biology of rabies virus: using stealth to reach the brain.Nature reviews. Microbiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Attenuated and highly neurovirulent rabies virus strains have distinct cellular tropisms. Highly neurovirulent strains such as the challenge virus standard (CVS) are highly neurotropic, whereas the attenuated strain ERA also infects nonneuronal cells. We report that both rabies virus strains infect activated murine lymphocytes and the human lymphoblastoid Jurkat T-cell line in vitro. The lymphocytes are more permissive to the attenuated ERA rabies virus strain than to the CVS strain in both cases. We also report that in contrast to that of the CVS strain, ERA viral replication induces apoptosis of infected Jurkat T cells, and cell death is concomitant with viral glycoprotein expression, suggesting that this protein has a role in the induction of apoptosis. Our data indicate that (i) rabies virus infects lymphocytes, (ii) lymphocyte infection with the attenuated rabies virus strain causes apoptosis, and (iii) apoptosis does not hinder rabies virus production. In contrast to CVS, ERA rabies virus and other attenuated rabies virus vaccines stimulate a strong immune response and are efficient live vaccines. The paradoxical finding that a rabies virus triggers a strong immune response despite the fact that it infects lymphocytes and induces apoptosis is discussed in terms of the function of apoptosis in the immune response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.