ArticleJournal of virology1997
The N-terminal region of the luteovirus readthrough domain determines virus binding to Buchnera GroEL and is essential for virus persistence in the aphid.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 160 citations in OpenAlex.
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- Small Talk: On the Possible Role of Trans-Kingdom Small RNAs during Plant-Virus-Vector Tritrophic Communication.Plants (Basel, Switzerland) · 2023Review
- Proteomic and Transcriptomic Analysis for Identification of Endosymbiotic Bacteria Associated with BYDV Transmission Efficiency byPlants (Basel, Switzerland) · 2022Article
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- Complex and simple translational readthrough signals in pea enation mosaic virus 1 and potato leafroll virus, respectively.PLoS pathogens · 2022Article
- Roles of Bacterial Symbionts in Transmission of Plant Virus by Hemipteran Vectors.Frontiers in microbiology · 2022Review
- Potato leafroll virus reduces Buchnera aphidocola titer and alters vector transcriptome responses.Scientific reports · 2021Article
- Genetic diversity and recombination between turnip yellows virus strains in Australia.Archives of virology · 2021Article
- Enhancing Capsid Proteins Capacity in Plant Virus-Vector Interactions and Virus Transmission.Cells · 2021Review
- Controlling Geminiviruses before Transmission: Prospects.Plants (Basel, Switzerland) · 2020Article
- Review
- An IntranuclearMicroorganisms · 2020Article
- Enhanced heat tolerance of viral-infected aphids leads to niche expansion and reduced interspecific competition.Nature communications · 2020Article
- Transmission of a New Polerovirus Infecting Pepper by the WhiteflyJournal of virology · 2019Article
- An aromatic amino acid and associated helix in the C-terminus of the potato leafroll virus minor capsid protein regulate systemic infection and symptom expression.PLoS pathogens · 2018Article
- A Stem-Loop Structure inJournal of virology · 2018Article
- Transmission ofFrontiers in microbiology · 2018Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Luteoviruses and the luteovirus-like pea enation mosaic virus (PEMV; genus Enamovirus) are transmitted by aphids in a circulative, nonreplicative manner. Acquired virus particles persist for several weeks in the aphid hemolymph, in which a GroEL homolog, produced by the primary endosymbiont of the aphid, is abundantly present. Six subgroup II luteoviruses and PEMV displayed a specific but differential affinity for Escherichia coli GroEL and GroEL homologs isolated from the endosymbiotic bacteria of both vector and nonvector aphid species. These observations suggest that the basic virus-binding capacity resides in a conserved region of the GroEL molecule, although other GroEL domains may influence the efficiency of binding. Purified luteovirus and enamovirus particles contain a major 22-kDa coat protein (CP) and lesser amounts of an approximately 54-kDa readthrough protein, expressed by translational readthrough of the CP into the adjacent open reading frame. Beet western yellows luteovirus (BWYV) mutants devoid of the readthrough domain (RTD) did not bind to Buchnera GroEL, demonstrating that the RTD (and not the highly conserved CP) contains the determinants for GroEL binding. In vivo studies showed that virions of these BWYV mutants were significantly less persistent in the aphid hemolymph than were virions containing the readthrough protein. These data suggest that the Buchnera GroEL-RTD interaction protects the virus from rapid degradation in the aphid. Sequence comparison analysis of the RTDs of different luteoviruses and PEMV identified conserved residues potentially important in the interaction with Buchnera GroEL.
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