ArticleJournal of virology1997
Antiviral immune responses in Itk-deficient mice.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- STAT3 S727 phosphorylation drives pathogenic Th17 differentiation and neuroinflammation in autoimmune disease.Journal of neuroinflammation · 2025Article
- The Seminiferous Epithelial Cycle of Spermatogenesis: Role of Non-receptor Tyrosine Kinases.Advances in experimental medicine and biology · 2021Article
- Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- CD8ImmunoHorizons · 2020Article
- Interleukin-2-Inducible T-Cell Kinase Deficiency Impairs Early Pulmonary Protection AgainstFrontiers in immunology · 2019Article
- IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells.Scientific reports · 2018Article
- Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight?Frontiers in immunology · 2018Review
- Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells.Frontiers in immunology · 2016Review
- The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection.Scientific reports · 2015Article
- Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases.Postdoc journal : a journal of postdoctoral research and postdoctoral affairs · 2014Article
- CD28 and ITK signals regulate autoreactive T cell trafficking.Nature medicine · 2013Article
- Partial defects of T-cell development associated with poor T-cell function.The Journal of allergy and clinical immunology · 2013Review
- Itk: the rheostat of the T cell response.Journal of signal transduction · 2011Article
- T-cell signaling regulated by the Tec family kinase, Itk.Cold Spring Harbor perspectives in biology · 2010Review
- Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.Immunological reviews · 2009Review
- The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.Immunological reviews · 2009Review
- Selective targeting of ITK blocks multiple steps of HIV replication.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk.European journal of immunology · 2007Article
- A role for the Tec family kinase ITK in regulating SEB-induced interleukin-2 production in vivo via c-jun phosphorylation.BMC immunology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice lacking Itk, a T-cell-specific protein tyrosine kinase, have reduced numbers of T cells and reduced responses to allogeneic major histocompatibility molecules. This study analyzed antiviral immune responses in mice deficient for Itk. Primary cytotoxic T-lymphocyte (CTL) responses were analyzed after infection with lymphocytic choriomeningitis virus (LCMV), vaccinia virus (VV), and vesicular stomatitis virus (VSV). Ex vivo CTL activity was consistently reduced by a factor of two to six for the different viruses. CTL responses after restimulation in vitro were similarly reduced unless exogenous cytokines were added. In the presence of interleukin-2 or concanavalin A supernatant, Itk-deficient and control mice responded similarly. Interestingly, while LCMV was completely eliminated by day 8 in both Itk-deficient and control mice, VV cleared from itk-/- mice with delayed kinetics. Antibody responses were evaluated after VSV infection. Both the T-cell-independent neutralizing immunoglobulin M (IgM) and the T-cell-dependent IgG responses were similar in Itk-deficient and control mice. Taken together, the results show that CTL responses are reduced in the absence of Itk whereas antiviral B-cell responses are not affected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.