ArticleJournal of virology1997
Requirements for different components of the host cell cytoskeleton distinguish ecotropic murine leukemia virus entry via endocytosis from entry via surface fusion.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Unique Structure and Distinctive Properties of the Ancient and Ubiquitous Gamma-Type Envelope Glycoprotein.Viruses · 2023Review
- ROCK1/MLC2 inhibition induces decay of viral mRNA in BPXV infected cells.Scientific reports · 2022Article
- Insights into Sensing of Murine Retroviruses.Viruses · 2020Review
- Article
- Actin dynamics in host-pathogen interaction.FEBS letters · 2018Review
- Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection.Journal of virology · 2016Article
- Characteristics of the cellular receptor influence the intracellular fate and efficiency of virus infection.Journal of virology · 2013Article
- Cytoskeleton disruption in J774 macrophages: consequences for lipid droplet formation and cholesterol flux.Biochimica et biophysica acta · 2012Article
- GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.Journal of virology · 2012Article
- Retrovirus entry by endocytosis and cathepsin proteases.Advances in virology · 2012Article
- Entry of tiger frog virus (an Iridovirus) into HepG2 cells via a pH-dependent, atypical, caveola-mediated endocytosis pathway.Journal of virology · 2011Article
- Involvement of caveolin-1 in the Jak-Stat signaling pathway and infectious spleen and kidney necrosis virus infection in mandarin fish (Siniperca chuatsi).Molecular immunology · 2011Article
- Infection of XC cells by MLVs and Ebola virus is endosome-dependent but acidification-independent.PloS one · 2011Article
- MLV glycosylated-Gag is an infectivity factor that rescues Nef-deficient HIV-1.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The Ezrin-radixin-moesin family member ezrin regulates stable microtubule formation and retroviral infection.Journal of virology · 2008Article
- Effects of identity minimization on Moloney murine leukemia virus template recognition and frequent tertiary template-directed insertions during nonhomologous recombination.Journal of virology · 2007Article
- Host cell cathepsins potentiate Moloney murine leukemia virus infection.Journal of virology · 2007Article
- Matrix fibronectin binds gammaretrovirus and assists in entry: new light on viral infections.Journal of virology · 2007Article
- Retroviral proteins that interact with the host cell cytoskeleton.Current opinion in immunology · 2007Review
- Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity.Antimicrobial agents and chemotherapy · 2007Article
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2 authors.
Funding
Abstract
Murine ecotropic leukemia viruses use a common receptor for entry into host cells; however, the site of virus fusion appears to differ with the host cell. Entry in mouse NIH 3T3 fibroblasts is by endocytosis, whereas entry in rat XC sarcoma cells is by surface fusion. We report here the identification of a step common to both entry pathways, as well as of a step unique to the endocytic pathway. Recent demonstration of the clustering of the virus receptor on rat cells suggested a possible interaction of the receptor with the cellular cytoskeleton (M. H. Woodard, W. A. Dunn, R. O. Laine, M. Malandro, R. McMahon, O. Simell, E. R. Block, and M. S. Kilberg, Am. J. Physiol. 266:E817-E824, 1994). We tested the hypothesis that such an interaction might influence receptor function. We found that entry into NIH 3T3 and XC cells was greatly diminished by the disruption of the actin network before but not shortly after virus internalization, suggesting the actin network plays a critical role in an early step common to both entry pathways. Disruption of microtubules before and shortly after virus internalization markedly reduced entry in NIH 3T3 cells, while entry into XC cells remained efficient. These data suggest that intact microtubules are required in a postpenetration step unique to efficient virus entry via endocytosis. The physiological function of the receptor was not affected by disruption of either the actin network or the microtubules, as the uptake of cationic amino acids in NIH 3T3 and XC cells was comparable to that in control cells even when the cytoskeleton remained disrupted for as long as 3 h.
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