ArticleAmerican journal of human genetics1997
The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.JAMA · 2009 · on this mapPooled it
- Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study.Journal of human genetics · 2015Trial
- IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans.Journal of lipid research · 2015Trial
- Apolipoprotein(a) production and clearance are associated with plasma IL-6 and IL-18 levels, dependent on ethnicity.Atherosclerosis · 2024Article
- Lipoprotein (a): When to Measure and How to Treat?Current atherosclerosis reports · 2021Review
- Beyond Lipoprotein(a) plasma measurements: Lipoprotein(a) and inflammation.Pharmacological research · 2021Review
- Performance evaluation of five lipoprotein(a) immunoassays on the Roche cobas c501 chemistry analyzer.Practical laboratory medicine · 2021Article
- Plasma lipoprotein(a) concentration as an independent predictor of hemodynamic progression of aortic valve stenosis.Molecular and cellular biochemistry · 2020Article
- PCSK9 in African Americans and Caucasians in Relation to Lp(a) Level, Apo(a) Size and Heritability.Journal of the Endocrine Society · 2020Article
- Heritability of apolipoprotein (a) traits in two-generational African-American and Caucasian families.Journal of lipid research · 2019Article
- Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.Nature communications · 2018Article
- Structure, function, and genetics of lipoprotein (a).Journal of lipid research · 2016Review
- Lipoprotein abnormalities in South Asians and its association with cardiovascular disease: Current state and future directions.World journal of cardiology · 2016Review
- Human Genetics and the Causal Role of Lipoprotein(a) for Various Diseases.Cardiovascular drugs and therapy · 2016Review
- New and emerging biomarkers in cardiovascular disease.Current diabetes reports · 2015Review
- Rhesus monkey (Macaca mulatta) lipoprotein(a) and apolipoprotein(a): high frequency of small size apolipoprotein(a) isoforms.Journal of medical primatology · 2015Article
- Immunopathology of desialylation: human plasma lipoprotein(a) and circulating anti-carbohydrate antibodies form immune complexes that recognize host cells.Molecular and cellular biochemistry · 2015Article
- Race is a key variable in assigning lipoprotein(a) cutoff values for coronary heart disease risk assessment: the Multi-Ethnic Study of Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Novel metabolic biomarkers of cardiovascular disease.Nature reviews. Endocrinology · 2014Review
- LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography.Lipids in health and disease · 2014Article
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Authors and funding
7 authors.
Funding
Abstract
The distributions of plasma lipoprotein(a), or Lp(a), levels differ significantly among ethnic groups. Individuals of African descent have a two- to threefold higher mean plasma level of Lp(a) than either Caucasians or Orientals. In Caucasians, variation in the plasma Lp(a) levels has been shown to be largely determined by sequence differences at the apo(a) locus, but little is known about either the genetic architecture of plasma Lp(a) levels in Africans or why they have higher levels of plasma Lp(a). In this paper we analyze the plasma Lp(a) levels of 257 sibling pairs from 49 independent African American families. The plasma Lp(a) levels were much more similar in the sibling pairs who inherited both apo(a) alleles identical by descent (IBD) (r = .85) than in those that shared one (r = .48) or no (r = .22) parental apo(a) alleles in common. On the basis of these findings, it was estimated that 78% of the variation in plasma Lp(a) levels in African Americans is attributable to polymorphism at either the apo(a) locus or sequences closely linked to it. Thus, the apo(a) locus is the major determinant of variation in plasma Lp(a) levels in African Americans, as well as in Caucasians. No molecular evidence was found for a common "high-expressing" apo(a) allele in the African Americans. We propose that the higher plasma levels of Lp(a) in Africans are likely due to a yet-to-be-identified trans-acting factor(s) that causes an increase in the rate of secretion of apo(a) or a decrease in its catabolism.
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