ArticleVirus genes1997
Evolution of the hemagglutinin gene of influenza B virus was driven by both positive and negative selection pressures.
Article in Virus genes, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Human broadly neutralizing influenza B virus antibodies recognizing hemagglutinin computationally optimized broadly reactive antigens.Frontiers in immunology · 2026Article
- Influenza B Virus Vaccine Innovation through Computational Design.Pathogens (Basel, Switzerland) · 2024Review
- Molecular markers of influenza B lineages and clades.Viruses · 2014Article
- Genetic analysis of influenza B viruses isolated in Uganda during the 2009-2010 seasons.Virology journal · 2013Article
- A report on the association of influenza B virus with respiratory tract infection of hospitalized children in Saudi Arabia.Saudi journal of biological sciences · 2009Article
- The evolutionary dynamics of human influenza B virus.Journal of molecular evolution · 2008Article
- Emergence of influenza A virus variants after prolonged shedding from pheasants.Journal of virology · 2007Article
- Evolution of surface and nonstructural-1 genes of influenza B viruses isolated in the Province of Québec, Canada, during the 1998-2001 period.Virus genes · 2003Article
- Reassortment and insertion-deletion are strategies for the evolution of influenza B viruses in nature.Journal of virology · 1999Article
- Identification of new influenza B virus variants by multiplex reverse transcription-PCR and the heteroduplex mobility assay.Journal of clinical microbiology · 1998Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nucleotide sequences of the hemagglutinin (HA) gene of twelve influenza B strains and their deduced amino acid sequences were extracted from the GenBank and compared to those of early isolates. Separate analyses of nonsynonymous and synonymous substitutions for the HA1 and HA2 regions individually indicate that the percentage of nonsynonymous substitutions in the HA1 ranges from 44.4-56.0% but in the HA2 from 0.0-6.5%. The results suggest that positive selection as well as negative selection played a role in the evolution of the influenza B HA gene with the former acting on the HA1 and the latter on the HA2.
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