ArticleBritish journal of cancer1997
Cytogenetic comparisons of synchronous carcinomas and polyps in patients with colorectal cancer.
Article in British journal of cancer, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- pRB, a tumor suppressor with a stabilizing presence.Trends in cell biology · 2011Review
- The chromosomal instability pathway in colon cancer.Gastroenterology · 2010Review
- Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.Genes, chromosomes & cancer · 2010Article
- Studying chromosome instability in the mouse.Biochimica et biophysica acta · 2008Review
- Centrosome replication, genomic instability and cancer.Leukemia · 2002Review
- Analysis of allelic imbalance in patients with colorectal cancer according to stage and presence of synchronous liver metastases.Annals of surgery · 2001Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thirty tumorous lesions from seven patients with colorectal cancer were short-term cultured and cytogenetically analysed: 16 non-adenomatous polyps, six adenomas, seven carcinomas, including one in polyp, and one lymph node metastasis. Clonal chromosome aberrations were found in 20 samples in 100% of the carcinomas, in 100% of the adenomas and in 37.5% of the non-adenomatous polyps, i.e. all ten lesions with a normal karyotype were histologically diagnosed as hyperplastic polyps. Although adenomas and carcinomas shared several karyotypic features, two chromosome aberrations, der(8;17)(q10;q10) and -14, were found in carcinomas but not in adenomas, indicating that they might be specifically associated with carcinoma development in the large bowel mucosa. The karyotypic similarity seen between the malignant and benign tumours in the same patient, and also sometimes among non-malignant polyps in the same case, indicates that these microscopically distinct lesions may be part of a single neoplastic clonal expansion.
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Registered trials
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