ArticleJapanese journal of cancer research : Gann1997
Reduced expression of cyclin-dependent kinase inhibitor p27Kip1 is associated with advanced stage and invasiveness of gastric carcinomas.
Article in Japanese journal of cancer research : Gann, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 132 citations in OpenAlex.
- Increased Expression of NPM1 Suppresses p27Cancers · 2020Article
- Article
- Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer.Journal of Cancer · 2016Article
- Prognostic implication of morphology, cyclinE2 and proliferation in EBV-associated T/NK lymphoproliferative disease in non-immunocompromised hosts.Orphanet journal of rare diseases · 2014Article
- Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer.Oncogene · 2012Article
- Endocrine dysfunction in p27Kip1 deficient mice and susceptibility to Wnt-1 driven breast cancer.Carcinogenesis · 2009Article
- Does the expression of cyclin E, pRb, and p21 correlate with prognosis in gastric adenocarcinoma?Digestive diseases and sciences · 2009Article
- p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability.Molecular and cellular biology · 2008Article
- Cellular and molecular aspects of gastric cancer.World journal of gastroenterology · 2006Review
- Article
- Prognostic significance of p21 and p53 expression in gastric cancer.The Korean journal of internal medicine · 2003Article
- Cell cycle regulators p27 and pRb in lymphomas - correlation with histology and proliferative activity.British journal of cancer · 2000Article
- ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency.Molecular and cellular biology · 2000Article
- Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases.The American journal of pathology · 2000Article
- p53/MDM2 Pathway Aberrations in Parathyroid Tumors: p21(WAF-1) and MDM2 Are Frequently Overexpressed in Parathyroid Adenomas.Endocrine pathology · 2000Article
- Protein expression of cell cycle regulator, p27Kip1, correlates with histopathological grade of non-Hodgkin's lymphoma.Japanese journal of cancer research : Gann · 1999Article
- Predictive value of decreased p27Kip1 protein expression for the recurrence-free and long-term survival of prostate cancer patients.British journal of cancer · 1999Article
- DCC expression is related to mucinous differentiation but not changes in expression of p21(WAF1/Cip1) and p27Kip1, apoptosis, cell proliferation and human papillomavirus infection in uterine cervical adenocarcinomas.British journal of cancer · 1999Article
- Expression of the cell cycle inhibitor p27KIP1 is a new prognostic marker associated with survival in epithelial ovarian tumors.The American journal of pathology · 1999Article
- p27 cell-cycle inhibitor is inversely correlated with lymph node metastases in right-sided colon cancer.Journal of clinical laboratory analysis · 1999Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced expression of a cyclin-dependent kinase inhibitor p27Kip1 has recently been shown to predict poor survival of patients with breast and colorectal cancers. We studied the expression of p27Kip1 in gastric carcinomas by northern blotting, western blotting and immunohistochemistry to determine whether lack of p27 has implications for aggressiveness of gastric cancer. Reduced expression of p27 was detected in 40% of the gastric carcinomas at the mRNA level, while it was detected in 57% at the protein level. No gross alterations of the p27 gene were observed in any of the cases examined by Southern blot analysis. Immunohistochemical studies revealed that the expression of p27 was well preserved in most of the gastric adenomas, whereas it was so in only 26% of the gastric carcinomas. Fifty-six percent of the carcinomas showed almost no p27-positive cells. Decrease of p27-positive cells significantly correlated with advanced stage, depth of tumor invasion and lymph node metastasis. The expression of p27 showed an inverse correlation with the expression of cyclin E. These findings suggest that reduction of p27Kip1 protein may reflect the progression of gastric carcinomas and may be an indicator of high-grade malignancy.
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