ArticleMolecular biology of the cell1997
Deletion of nudC, a nuclear migration gene of Aspergillus nidulans, causes morphological and cell wall abnormalities and is lethal.
Article in Molecular biology of the cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- NUDC Is Critical for Mitosis and Postmitotic Cell Maintenance Through Its Modulation of Dynein and Actin Cytoskeletal Reorganization.Advances in experimental medicine and biology · 2025Review
- NUDC is critical for rod photoreceptor function, maintenance, and survival.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Small Sized Yet Powerful: Nuclear Distribution C Proteins in Plants.Plants (Basel, Switzerland) · 2023Review
- NudC regulated Lis1 stability is essential for the maintenance of dynamic microtubule ends in axon terminals.iScience · 2022Article
- Overexpression of theFrontiers in plant science · 2020Article
- NudC regulates photoreceptor disk morphogenesis and rhodopsin localization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Genetic Interactions BetweenG3 (Bethesda, Md.) · 2018Article
- A WDR Gene Is a Conserved Member of a Chitin Synthase Gene Cluster and Influences the Cell Wall in Aspergillus nidulans.International journal of molecular sciences · 2016Article
- Article
- Structural features and chaperone activity of the NudC protein family.Journal of molecular biology · 2011Article
- The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.The Journal of biological chemistry · 2010Article
- NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Integrative analysis of the heat shock response in Aspergillus fumigatus.BMC genomics · 2010Article
- Partitioning the apical domain of the Arabidopsis embryo requires the BOBBER1 NudC domain protein.The Plant cell · 2009Article
- The mammalian NudC-like genes: a family with functions other than regulating nuclear distribution.Cellular and molecular life sciences : CMLS · 2009Review
- The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro.Cell stress & chaperones · 2009Article
- The nuclear migration protein NUDF/LIS1 forms a complex with NUDC and BNFA at spindle pole bodies.Eukaryotic cell · 2008Article
- A mammalian NudC-like protein essential for dynein stability and cell viability.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Expression of asexual developmental regulator gene abaA is affected in the double mutants of classes I and II chitin synthase genes, chsC and chsA, of Aspergillus nidulans.Current genetics · 2005Review
- Class I and class II chitin synthases are involved in septum formation in the filamentous fungus Aspergillus nidulans.Eukaryotic cell · 2005Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear migration is required for normal development in both higher and lower eukaryotes. In fungi this process is mediated by cytoplasmic dynein. It is believed that this motor protein is anchored to the cell membrane and moves nuclei by capturing and pulling on spindle pole body microtubules. To date, four genes have been identified and shown to be required for this process in Aspergillus nidulans. The nudA and nudG genes, respectively, encode the heavy and light chains of cytoplasmic dynein, and the nudF and nudC gene products encode proteins of 49 and 22 kDa. The precise biochemical functions of the nudF and nudC genes have not yet been identified. In this report we further investigate NUDC protein function by deleting the nudC gene. Surprisingly, although deletion of nudA and nudF affect nuclear migration, deletion of nudC profoundly affected the morphology and composition of the cell wall. Spores of the strain deleted for nudC grew spherically and lysed. The thickness of the cell wall was increased in the deletion mutant and wall polymer composition was abnormal. This phenotype could be repressed by growth on osmotically buffered medium at low temperature. Similar, but less severe, effects were also noted in a strain depleted for NUDC by down-regulation. These results suggest a possible relationship between fungal cell wall biosynthesis and nuclear migration.
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