ArticleSurgery today1997
Clinical significance of extrabowel skipped cancer infiltration in rectal cancer.
Article in Surgery today, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 83 citations in OpenAlex.
- Utilizing machine learning algorithms for predicting risk factors for bone metastasis from right-sided colon carcinoma after complete mesocolic excision: a 10-year retrospective multicenter study.Discover oncology · 2024Article
- The past, present, and future of tumour deposits in colorectal cancer: Advancing staging for improved prognosis and treatment decision-making.Journal of cellular and molecular medicine · 2024Review
- Combining pathological risk factors and T, N staging to optimize the assessment for risk stratification and prognostication in low-risk stage III colon cancer.World journal of surgical oncology · 2024Article
- Incorporation of perigastric tumor deposits into the TNM staging system for primary gastric cancer.World journal of gastrointestinal oncology · 2023Article
- Tumor deposits in colorectal cancer: Refining their definition in the TNM system.Annals of gastroenterological surgery · 2023Review
- Identifying the long-term survival beneficiary of chemotherapy for stage N1c sigmoid colon cancer.Scientific reports · 2022Article
- Tumor Deposits in Stage III Colon Cancer: Correlation With Other Histopathologic Variables, Prognostic Value, and Risk Stratification-Time to Consider "N2c".American journal of clinical oncology · 2020Article
- Predictive and Prognostic Factors of Synchronous Colorectal Lung-Limited Metastasis.Gastroenterology research and practice · 2020Article
- Prognostic Importance of Tumor Deposits in the Ipsilateral Axillary Region of Breast Cancer Patients.Pathology oncology research : POR · 2019Article
- Prognostic significance and role in TNM stage of tumor deposits in esophageal cancer.Journal of thoracic disease · 2017Article
- Prognostic significance of perigastric tumor deposits in patients with primary gastric cancer.BMC surgery · 2017Article
- Tumor deposits: markers of poor prognosis in patients with locally advanced rectal cancer following neoadjuvant chemoradiotherapy.Oncotarget · 2016Article
- Unusual osseous metastases from rectal adenocarcinoma: a case report and review of the literature.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Review
- Prognostic value of tumor shrinkage versus fragmentation following radiochemotherapy and surgery for rectal cancer.Virchows Archiv : an international journal of pathology · 2015Article
- Tumor deposits in rectal adenocarcinoma after neoadjuvant chemoradiation are associated with poor prognosis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2014Article
- Effect of tumor deposits on overall survival in colorectal cancer patients with regional lymph node metastases.Journal of rural medicine : JRM · 2014Article
- Can the tumor deposits be counted as metastatic lymph nodes in the UICC TNM staging system for colorectal cancer?PloS one · 2012Article
- Lymph node negative colorectal cancers with isolated tumor deposits should be classified and treated as stage III.Annals of surgical oncology · 2010Article
- Microscopic cancer cell spread in gastric cancer: whole-section analysis of mesogastrium.Langenbeck's archives of surgery · 2009Article
- Comment on: a clinicopathological investigation of "tumor nodules" in colorectal cancer.Surgery today · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During a pathologic examination, cancer nodules, and not lymph node metastases, are often seen in the fatty tissue outside the rectum. The significance of this type of cancer spread, which is called extrabowel skipped cancer infiltration (ex), was investigated. A total of 369 patients who underwent resection of rectal adenocarcinoma between 1980 and 1992 were reviewed. All surgical specimens were examined microscopically to determine if ex existed in the fatty tissue outside the rectum or in the detached fatty tissue around the dissected lymph nodes. The ex was divided into four patterns: scattering (sct), vessel invasion (ves), neural invasion (ni), and nodular (nd). Ex was found in 130 patients (35.2%). Of these, 19 were sct, 58 ves, 21 ni, and 111 nd. The overall recurrence rates after curative resection were 52.8% in the ex(+) group and 24.0% in the ex(-) group (P < 0.001). The local recurrence rates were 35.8% and 14.9%, respectively (P < 0.01). The ex(+) group exhibited a significantly worse survival than the ex(-) group (P < 0.001). The presence of ex indicates the aggressive biologic activity of rectal cancer. Ex may be a significant prognostic predictor in these patients. Therefore, such treatments as extended dissection, postoperative adjuvant therapy, and a meticulous follow-up are all considered to be necessary for patients with ex.
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