ArticleSurgery today1997
Prognostic significance of E-cadherin expression in human colorectal cancer tissue.
Article in Surgery today, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Effect of E-cadherin on Prognosis of Colorectal Cancer: A Meta-Analysis Update.Molecular diagnosis & therapy · 2022Pooled it
- Downregulated E-cadherin expression indicates worse prognosis in Asian patients with colorectal cancer: evidence from meta-analysis.PloS one · 2013Pooled it
- Article
- Utility of immunohistochemical expression of E-cadherin in colorectal carcinoma.Przeglad gastroenterologiczny · 2022Article
- E-cadherin and NEDD9 expression in primary colorectal cancer, metastatic lymph nodes and liver metastases.Oncology letters · 2019Article
- The clinicopathologic significance of extranodal tumor extension in locally advanced (pT3) colorectal adenocarcinoma and its association with the loss of E-cadherin expression.International journal of clinical and experimental pathology · 2019Article
- Review
- Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma.Oncotarget · 2017Article
- Article
- Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin.Cell host & microbe · 2013Article
- Differences in the expression of epithelial-mesenchymal transition related molecules between primary tumors and pulmonary metastatic tumors in colorectal cancer.Surgery today · 2013Article
- Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis.Molecular biology reports · 2012Article
- Cell surface markers in colorectal cancer prognosis.International journal of molecular sciences · 2010Review
- Higher CO2-insufflation pressure inhibits the expression of adhesion molecules and the invasion potential of colon cancer cells.World journal of gastroenterology · 2009Article
- Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients.British journal of cancer · 2006Article
- Prognostic significance of dysadherin expression in advanced colorectal carcinoma.British journal of cancer · 2003Article
- [Clinical, pathological and molecular prognostic factors in colorectal carcinomas].Der Pathologe · 2003Review
- Expression of E-cadherin, b-catenin, and Ki-67 in goblet cell carcinoids of the appendix: an immunohistochemical study with clinical correlation.Endocrine pathology · 2002Article
- Cell surface molecules and their prognostic values in assessing colorectal carcinomas.Annals of surgery · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of E-cadherin was determined by immunohistochemical staining in tumor tissue and in adjacent normal mucosae taken from 100 resected specimens of colorectal carcinomas. The expression of E-cadherin was preserved in all normal mucosae, but in the tumor tissue specimens it was preserved in 43, heterogeneous in 32, and lost in 25 samples. The lost or heterogeneous expression of E-cadherin correlated closely to the following: an advanced clinical stage of colorectal cancer, advanced tumor penetration, undifferentiated tumor histology, widespread lymph node involvement, liver metastasis, and permeation into the lymphatic and venous channels. The lost or heterogeneous expression of E-cadherin in tumor tissue was also significantly associated with an increased incidence of tumor recurrence after apparently curative resection, a reduced overall survival rate, and a reduced disease-free patient survival rate. A multivariate analysis disclosed that the expression of E-cadherin in tumor tissue was a significant prognostic variable independent of other clinicopathological features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.