ArticleThe EMBO journal1997
Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 157 citations in OpenAlex.
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- Single-cell resolution long-term luciferase imaging in cultivatedmicroPublication biology · 2020Article
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- SUR-8 interacts with PP1-87B to stabilize PERIOD and regulate circadian rhythms in Drosophila.PLoS genetics · 2019Article
- Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay.Neuron · 2019Article
- Intestinal Stem Cells Exhibit Conditional Circadian Clock Function.Stem cell reports · 2018Article
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- Iron Sulfur and Molybdenum Cofactor Enzymes Regulate theFrontiers in physiology · 2018Article
- A new promoter element associated with daily time keeping in Drosophila.Nucleic acids research · 2017Article
- Fluorescence circadian imaging reveals a PDF-dependent transcriptional regulation of the Drosophila molecular clock.Scientific reports · 2017Article
- Reciprocal regulation of carbon monoxide metabolism and the circadian clock.Nature structural & molecular biology · 2017Article
- Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model.Scientific reports · 2016Article
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5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A new regulatory element necessary for the correct temporal expression of the period (per) gene was identified by monitoring real-time per expression in living individual flies carrying two different period-luciferase transgenes. luciferase RNA driven from only the per promoter was not sufficient to replicate the normal pattern of per RNA cycling; however, a per-luc fusion RNA driven from a transgene containing additional per sequences cycled identically to endogenous per. The results indicate the existence of at least two circadian-regulated elements--one within the promoter and one within the transcribed portion of the per gene. Phase and amplitude analysis of both per-luc transgenes revealed that normal per expression requires the regulation of these elements at distinct phases and suggests a mechanism by which biological clocks sustain high-amplitude feedback oscillations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.