ArticleThe EMBO journal1997
G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease.Annual review of biophysics · 2024Review
- Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Structure of APP-C99Biochimica et biophysica acta. Biomembranes · 2018Article
- Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development.Frontiers in molecular neuroscience · 2016Article
- The Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocation.Cell research · 2014Article
- FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines.Journal of biosciences · 2014Article
- Amyloid β precursor protein as a molecular target for amyloid β--induced neuronal degeneration in Alzheimer's disease.Neurobiology of aging · 2013Review
- G proteins, p60TRP, and neurodegenerative diseases.Molecular neurobiology · 2013Review
- Viruses and neurodegeneration.Virology journal · 2013Review
- Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling.Journal of toxicology · 2012Article
- First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia.Molecular neurodegeneration · 2010Article
- Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders.Molecular neurobiology · 2010Review
- Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes.Current molecular medicine · 2009Review
- Molecular mechanisms of go signaling.Neuro-Signals · 2009Review
- Neuronal cell death in Alzheimer's disease and a neuroprotective factor, humanin.Current neuropharmacology · 2006Article
- The insect homologue of the amyloid precursor protein interacts with the heterotrimeric G protein Go alpha in an identified population of migratory neurons.Developmental biology · 2005Article
- Humanin: after the discovery.Molecular neurobiology · 2004Review
- G-protein beta subunit of Cochliobolus heterostrophus involved in virulence, asexual and sexual reproductive ability, and morphogenesis.Eukaryotic cell · 2004Article
- DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
In familial Alzheimer's disease (FAD), three missense mutations, V642I, V642F and V642G, that co-segregate with the disease phenotype have been discovered in the 695 amino acid form of the amyloid precursor protein APP. Expression of these mutants causes a COS cell NK1 clone to undergo pertussis toxin-sensitive apoptosis in an FAD trait-linked manner by activating the G protein Go, which consists of G alpha(o) and G betagamma subunits. We investigated which subunit was responsible for the induction of apoptosis by V642I APP in NK1 cells. In the same system, expression of mutationally activated G alpha(o) or G alpha(i) induced little apoptosis. Apoptosis by V642I APP was antagonized by the overexpression of the carboxy-terminal amino acids 495-689 of the beta-adrenergic receptor kinase-1, which blocks the specific functions of G betagamma. Co-transfection of G beta2gamma2 cDNAs, but not that of other G beta(x)gamma(z) (x = 1-3; z = 2, 3), induced DNA fragmentation in a manner sensitive to bcl-2. These data implicate G betagamma as a cell death mediator for the FAD-associated mutant of APP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.