ArticleThe EMBO journal1997
The inner nuclear membrane protein LAP1 forms a native complex with B-type lamins and partitions with spindle-associated mitotic vesicles.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 73 citations in OpenAlex.
- Nucleus Mechanosensing in Cardiomyocytes.International journal of molecular sciences · 2023Review
- Review
- Loss of the Nuclear Envelope Protein LAP1B Disrupts the Myogenic Differentiation of Patient-Derived Fibroblasts.International journal of molecular sciences · 2022Article
- The Nuclear Lamina.Cold Spring Harbor perspectives in biology · 2022Review
- Nuclear Accumulation of LAP1:TRF2 Complex during DNA Damage Response Uncovers a Novel Role for LAP1.Cells · 2020Article
- Combined loss of LAP1B and LAP1C results in an early onset multisystemic nuclear envelopathy.Nature communications · 2019Article
- DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces.Frontiers in cell and developmental biology · 2019Article
- Article
- Review
- Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum.Journal of cell science · 2015Article
- LAP1 is a crucial protein for the maintenance of the nuclear envelope structure and cell cycle progression.Molecular and cellular biochemistry · 2015Article
- Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation.Oncogenesis · 2014Article
- Identification of a novel human LAP1 isoform that is regulated by protein phosphorylation.PloS one · 2014Article
- Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance.Developmental cell · 2013Article
- Partners and post-translational modifications of nuclear lamins.Chromosoma · 2013Review
- Article
- Nuclear lamins.Cold Spring Harbor perspectives in biology · 2010Review
- Interaction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion.The Journal of biological chemistry · 2009Article
- Article
- TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.Journal of cell science · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have examined the in situ organization and nearest neighbours of the 'lamina-associated polypeptide-1' (LAP1), a type II membrane protein and a major constituent of the mammalian nuclear envelope. We show here that, during interphase, LAP1 forms multimeric assemblies which are suspended in the inner nuclear membrane and are specifically associated with B-type lamins. The LAP1-lamin B complex is distinct from analogous complexes formed by the 'lamina-associated polypeptide-2' (LAP2), another inner nuclear membrane protein, and includes a protein kinase. Upon nuclear envelope breakdown, LAP1 partitions with mitotic vesicles which carry nuclear lamin B. The LAP1 vesicles can be distinguished from fragments of the nuclear envelope containing LAP2 and exhibit a striking co-alignment with spindle microtubules. These observations suggest that the inner nuclear membrane comprises discrete territories which accommodate specific integral membrane proteins and are differentially disassembled during mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.