ArticleThe EMBO journal1997
Molecular architecture of the ER translocase probed by chemical crosslinking of Sss1p to complementary fragments of Sec61p.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC.BMC biology · 2021Article
- Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.PLoS genetics · 2021Article
- The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.The Journal of biological chemistry · 2020Article
- Article
- ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7.BMC cell biology · 2013Article
- BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER.The EMBO journal · 2012Article
- Secretory pathway-dependent localization of the Saccharomyces cerevisiae Rho GTPase-activating protein Rgd1p at growth sites.Eukaryotic cell · 2012Article
- Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity.Molecular biology of the cell · 2011Article
- Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence.The Biochemical journal · 2011Article
- Sss1p is required to complete protein translocon activation.The Journal of biological chemistry · 2010Article
- A novel role for Gtb1p in glucose trimming of N-linked glycans.Glycobiology · 2009Article
- Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum.Molecular biology of the cell · 2004Article
- Four cysteines of the membrane protein DsbB act in concert to oxidize its substrate DsbA.The EMBO journal · 2002Article
- Characterization of a differentially expressed protein that shows an unusual localization to intracellular membranes in Leishmania major.The Biochemical journal · 2001Article
- Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.The EMBO journal · 2001Article
- LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum.The EMBO journal · 2000Article
- Role of the cytoplasmic segments of Sec61alpha in the ribosome-binding and translocation-promoting activities of the Sec61 complex.The Journal of cell biology · 2000Article
- Topology studies with biosynthetic fragments identify interacting transmembrane regions of the human red-cell anion exchanger (band 3; AE1).The Biochemical journal · 1999Article
- Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.The Journal of cell biology · 1999Article
- Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking.Journal of bacteriology · 1999Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The heterotrimeric Sec61p complex is a key component of the protein translocation apparatus of the endoplasmic reticulum membrane. The complex characterized from yeast includes Sec61p, a 10-transmembrane-domain membrane protein which has a direct interaction with Sss1p, a small C-terminal anchor protein. In order to gain some insight into the architecture of this complex we have functionally expressed Sec61p as complementary N- and C-terminal fragments. Chemical crosslinking of Sss1p to specific Sec61p fragments in these functional combinations and suppression of sec61 mutants by over-expression of Sss1p have led to identification of the region which includes transmembrane domains TM6, TM7 and TM8 (amino acid residues L232-R406) of Sec61p as a major site of interaction with Sss1p.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.