ArticleThe Journal of cell biology1997
Conservation of the centromere/kinetochore protein ZW10.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 113 citations in OpenAlex.
- ZW10: an emerging orchestrator of organelle dynamics during the cell division cycle.Journal of molecular cell biology · 2024Review
- Phylogenetic analysis of mammalian SIP30 sequences indicating accelerated adaptation of functional domain in primates.Biochemistry and biophysics reports · 2024Article
- RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells.EMBO reports · 2023Article
- QTL Analysis of Stem Elongation and Flowering Time in Lettuce Using Genotyping-by-Sequencing.Genes · 2021Article
- Dynamics of kinetochore structure and its regulations during mitotic progression.Cellular and molecular life sciences : CMLS · 2020Review
- Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.Nature cell biology · 2018Article
- Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis.The Journal of biological chemistry · 2018Article
- Rs2459976 inOncotarget · 2018Article
- NudE regulates dynein at kinetochores but is dispensable for other dynein functions in theJournal of cell science · 2018Article
- Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly.The Journal of cell biology · 2017Article
- Review
- Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells.Genes & development · 2010Article
- The spindle assembly checkpoint in Caenorhabditis elegans: one who lacks Mad1 becomes mad one.Cell cycle (Georgetown, Tex.) · 2009Article
- Key players in chromosome segregation in Caenorhabditis elegans.Frontiers in bioscience (Landmark edition) · 2009Review
- SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans.The Journal of cell biology · 2008Article
- Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.The Journal of cell biology · 2008Article
- Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.Molecular biology of the cell · 2007Article
- Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control.Oncogene · 2006Article
- Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function.The Journal of cell biology · 2006Article
- Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins.Genome biology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mutations in the essential Drosophila melanogaster gene zw10 disrupt chromosome segregation, producing chromosomes that lag at the metaphase plate during anaphase of mitosis and both meiotic divisions. Recent evidence suggests that the product of this gene, DmZW10, acts at the kinetochore as part of a tension-sensing checkpoint at anaphase onset. DmZW10 displays an intriguing cell cycle-dependent intracellular distribution, apparently moving from the centromere/kinetochore at prometaphase to kinetochore microtubules at metaphase, and back to the centromere/kinetochore at anaphase (Williams, B.C., M. Gatti, and M.L. Goldberg. 1996. J. Cell Biol. 134:1127-1140). We have identified ZW10-related proteins from widely diverse species with divergent centromere structures, including several Drosophilids, Caenorhabditis elegans, Arabidopsis thaliana, Mus musculus, and humans. Antibodies against the human ZW10 protein display a cell cycle-dependent staining pattern in HeLa cells strikingly similar to that previously observed for DmZW10 in dividing Drosophila cells. Injections of C. elegans ZW10 antisense RNA phenocopies important aspects of the mutant phenotype in Drosophila: these include a strong decrease in brood size, suggesting defects in meiosis or germline mitosis, a high percentage of lethality among the embryos that are produced, and the appearance of chromatin bridges at anaphase. These results indicate that at least some aspects of the functional role of the ZW10 protein in ensuring proper chromosome segregation are conserved across large evolutionary distances.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.