ArticleJournal of bioenergetics and biomembranes1997
Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal.
Article in Journal of bioenergetics and biomembranes, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 78 citations in OpenAlex.
- Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans.BMC research notes · 2014Trial
- An AlphaFold Structure Analysis of COQ2 as Key a Component of the Coenzyme Q Synthesis Complex.Antioxidants (Basel, Switzerland) · 2024Article
- Levels of Plasma Coenzyme QAntioxidants (Basel, Switzerland) · 2022Article
- Coenzyme Q regulates the expression of essential genes of the pathogen- and xenobiotic-associated defense pathway in C. elegans.Journal of clinical biochemistry and nutrition · 2015Article
- The regulation of coenzyme q biosynthesis in eukaryotic cells: all that yeast can tell us.Molecular syndromology · 2014Article
- Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications.Molecular neurobiology · 2013Review
- Association between genetic variants in the Coenzyme Q10 metabolism and Coenzyme Q10 status in humans.BMC research notes · 2011Article
- Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis.PloS one · 2009Article
- Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress.The journals of gerontology. Series A, Biological sciences and medical sciences · 2008Article
- Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Adaptations to oxidative stress induced by vitamin E deficiency in rat liver.Journal of bioenergetics and biomembranes · 2006Article
- Coenzyme Q-dependent functions of plasma membrane in the aging process.Age (Dordrecht, Netherlands) · 2005Article
- A novel plasma membrane quinone reductase and NAD(P)H:quinone oxidoreductase 1 are upregulated by serum withdrawal in human promyelocytic HL-60 cells.Journal of bioenergetics and biomembranes · 2002Article
- Neutral magnesium-dependent sphingomyelinase from liver plasma membrane: purification and inhibition by ubiquinol.Journal of bioenergetics and biomembranes · 2001Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum provides cultured cells with survival factors required to maintain growth. Its withdrawal induces the development of programmed cell death. HL-60 cells were sensitive to serum removal, and an increase of lipid peroxidation and apoptosis was observed. Long-term treatment with ethidium bromide induced the mitochondria-deficient rho(o)HL-60 cell line. These cells were surprisingly more resistant to serum removal, displaying fewer apoptotic cells and lower lipid peroxidation. HL-60 cells contained less ubiquinone at the plasma membrane than rho(o)HL-60 cells. Both cell types increased plasma membrane ubiquinone in response to serum removal, although this increase was much higher in rho(o) cells. Addition of ubiquinone to both cell cultures in the absence of serum improved cell survival with decreasing lipid peroxidation and apoptosis. Ceramide was accumulated after serum removal in HL-60 but not in rho(o)HL-60 cells, and exogenous ubiquinone reduced this accumulation. These results demonstrate a relationship between ubiquinone levels in the plasma membrane and the induction of serum withdrawal-induced apoptosis, and ceramide accumulation. Thus, ubiquinone, which is a central component of the plasma membrane electron transport system, can represent a first level of protection against oxidative damage caused by serum withdrawal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.