ReviewGlycoconjugate journal1997
Regulation of N-acetylglucosaminyltransferase V and Asn-linked oligosaccharide beta(1,6) branching by a growth factor signaling pathway and effects on cell adhesion and metastatic potential.
Review in Glycoconjugate journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 61 citations in OpenAlex.
- N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes.Molecular cancer research : MCR · 2021Article
- Comparison of the methods for profilingRSC advances · 2018Article
- Glycan analysis of colorectal cancer samples reveals stage-dependent changes in CEA glycosylation patterns.Clinical proteomics · 2018Article
- Biological roles of glycans.Glycobiology · 2017Review
- Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.Journal of gastroenterology · 2014Article
- Transcriptional regulation of fucosyltransferase 1 gene expression in colon cancer cells.TheScientificWorldJournal · 2013Article
- Regulation of MMP-2 expression and activity by β-1,3-N-acetylglucosaminyltransferase-8 in AGS gastric cancer cells.Molecular biology reports · 2011Article
- Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis.British journal of cancer · 2007Article
- Characterization of glycosylation and adherent properties of melanoma cell lines.Cancer immunology, immunotherapy : CII · 2006Article
- The structure of the oligosaccharides of N-cadherin from human melanoma cell lines.Glycoconjugate journal · 2004Article
- Glycosylation defining cancer malignancy: new wine in an old bottle.Proceedings of the National Academy of Sciences of the United States of America · 2002Review
- Modulation of the basal activity of phosphatidylinositol-3-kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.Glycoconjugate journal · 2000Article
- Regulation of expression of the human beta-1,2-N-acetylglucosaminyltransferase II gene (MGAT2) by Ets transcription factors.The Biochemical journal · 2000Article
- A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment.Glycoconjugate journal · 1998Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence demonstrates that the changes in the size of N-linked oligosaccharides that correlate with cell transformation and tumorigenicity are due at least in part to the regulation of expression of a glycosyltransferase involved in the branching of N-linked structures, N-acetylglucosaminyltransferase V or GlcNAc-T V. Studies have shown that the increases in GlcNAc-T V expression after oncogenic transformation are most likely caused by direct effects on the GlcNAc-T V promoter by the Ets family of transcriptional activators, which are up-regulated by a cellular proliferation signaling pathway. This pathway begins with growth factor receptors that activate tyrosine kinases at the cell surface and proceeds through src, ras, and raf. Additional evidence for the association between cellular proliferation and GlcNAc-T V expression will be presented, as well as a discussion of the effects of beta(1,6) branching on several of the phenotypes of oncogenically transformed cells, including metastatic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.