ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
All-or-none Ca2+ release from intracellular stores triggered by Ca2+ influx through voltage-gated Ca2+ channels in rat sensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Endoplasmic reticular stress as an emerging therapeutic target for chronic pain: a narrative review.British journal of anaesthesia · 2024Review
- Review
- Ca2+ removal by the plasma membrane Ca2+-ATPase influences the contribution of mitochondria to activity-dependent Ca2+ dynamics in Aplysia neuroendocrine cells.Journal of neurophysiology · 2016Article
- Brief low [Mg(2+)]o-induced Ca(2+) spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2016Article
- Ryanodine-receptor-driven intracellular calcium dynamics underlying spatial association of synaptic plasticity.Journal of computational neuroscience · 2015Article
- A Threshold Shear Force for Calcium Influx in an Astrocyte Model of Traumatic Brain Injury.Journal of neurotrauma · 2015Article
- The upregulation of α2δ-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Assessment of TTX-s and TTX-r Action Potential Conduction along Neurites of NGF and GDNF Cultured Porcine DRG Somata.PloS one · 2015Article
- Stim and Orai proteins in neuronal Ca(2+) signaling and excitability.Frontiers in cellular neuroscience · 2015Review
- Role of intracellular calcium stores in hair-cell ribbon synapse.Frontiers in cellular neuroscience · 2014Review
- Microscopic heat pulse-induced calcium dynamics in single WI-38 fibroblasts.Biophysics (Nagoya-shi, Japan) · 2014Article
- Regulation of dendritic calcium release in striatal spiny projection neurons.Journal of neurophysiology · 2013Article
- Article
- Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.Biochimica et biophysica acta · 2013Article
- Stress, caffeine and ethanol trigger transient neurological dysfunction through shared mechanisms in a mouse calcium channelopathy.Neurobiology of disease · 2013Article
- Cellular signal mechanisms of reward-related plasticity in the hippocampus.Neural plasticity · 2012Review
- Regulation of Kv channel expression and neuronal excitability in rat medial nucleus of the trapezoid body maintained in organotypic culture.The Journal of physiology · 2010Article
- Maturation and long-term hypoxia alters Ca2+-induced Ca2+ release in sheep cerebrovascular sympathetic neurons.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- Homeostatic and stimulus-induced coupling of the L-type Ca2+ channel to the ryanodine receptor in the hippocampal neuron in slices.Cell calcium · 2009Article
- Advancing age alters the contribution of calcium release from smooth endoplasmic reticulum stores in superior cervical ganglion cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Article
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Authors and funding
2 authors.
Funding
Abstract
Ca2+-induced Ca2+ release (CICR) from intracellular stores amplifies the Ca2+ signal that results from depolarization. In neurons, the amplification has been described as a graded process. Here we show that regenerative CICR develops as an all-or-none event in cultured rat dorsal root ganglion neurons in which ryanodine receptors have been sensitized to Ca2+ by caffeine. We used indo-1-based microfluorimetry in combination with whole-cell patch-clamp recording to characterize the relationship between Ca2+ influx and Ca2+ release. Regenerative release of Ca2+ was triggered when action potential-induced Ca2+ influx increased the intracellular Ca2+ concentration ([Ca2+]i) above threshold. The threshold was modulated by caffeine and intraluminal Ca2+. A relative refractory period followed CICR. The pharmacological profile of the response was consistent with Ca2+ influx through voltage-gated Ca2+ channels triggering release from ryanodine-sensitive stores. The activation of a suprathreshold response increased more than fivefold the amplitude and duration of the [Ca2+]i transient. The switch to a suprathreshold response was regulated very precisely in that addition of a single action potential to the stimulus train was sufficient for this transformation. Confocal imaging experiments showed that CICR facilitated propagation of the Ca2+ signal from the plasmalemma to the nucleus. This all-or-none reaction may serve as a switch that determines whether a given electrical signal will be transduced into a local or widespread increase in [Ca2+]i.
Indexed as
Identifiers
9295386PMC6573443What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.