ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Distinct contributions of high- and low-voltage-activated calcium currents to afterhyperpolarizations in cholinergic nucleus basalis neurons of the guinea pig.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Physiology and Therapeutic Potential of SK, H, and M Medium AfterHyperPolarization Ion Channels.Frontiers in molecular neuroscience · 2021Review
- Similar nicotinic excitability responses across the developing hippocampal formation are regulated by small-conductance calcium-activated potassium channels.Journal of neurophysiology · 2018Article
- Small-Conductance Ca2+-Activated Potassium Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells.Hypertension (Dallas, Tex. : 1979) · 2016Article
- The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases.Expert opinion on therapeutic targets · 2013Review
- Sub- and suprathreshold adaptation currents have opposite effects on frequency tuning.The Journal of physiology · 2012Article
- Adult mouse basal forebrain harbors two distinct cholinergic populations defined by their electrophysiology.Frontiers in behavioral neuroscience · 2012Article
- Enhanced calcium buffering in F344 rat cholinergic basal forebrain neurons is associated with age-related cognitive impairment.Journal of neurophysiology · 2009Article
- Ca(2+) signaling by T-type Ca(2+) channels in neurons.Pflugers Archiv : European journal of physiology · 2009Review
- Spike-rate coding and spike-time coding are affected oppositely by different adaptation mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Accumulation of cytoplasmic calcium, but not apamin-sensitive afterhyperpolarization current, during high frequency firing in rat subthalamic nucleus cells.The Journal of physiology · 2008Article
- Apamin-sensitive calcium-activated potassium currents (SK) are activated by persistent calcium currents in rat motoneurons.Journal of neurophysiology · 2007Article
- Recruitment of apical dendritic T-type Ca2+ channels by backpropagating spikes underlies de novo intrinsic bursting in hippocampal epileptogenesis.The Journal of physiology · 2007Article
- The SK channel blocker apamin inhibits slow afterhyperpolarization currents in rat gonadotropin-releasing hormone neurones.The Journal of physiology · 2006Article
- Control of spontaneous firing patterns by the selective coupling of calcium currents to calcium-activated potassium currents in striatal cholinergic interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- A-, T-, and H-type currents shape intrinsic firing of developing rat abducens motoneurons.The Journal of physiology · 2003Article
- Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Control of the propagation of dendritic low-threshold Ca(2+) spikes in Purkinje cells from rat cerebellar slice cultures.The Journal of physiology · 2002Article
- The role of N-, Q- and R-type Ca2+ channels in feedback inhibition of ACh release from rat basal forebrain neurones.The Journal of physiology · 1999Article
- Signaling complexes of voltage-gated calcium channels.Channels (Austin, Tex.)Review
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4 authors.
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Abstract
The contributions made by low- (LVA) and high-voltage-activated (HVA) calcium currents to afterhyperpolarizations (AHPs) of nucleus basalis (NB) cholinergic neurons were investigated in dissociated cells. Neurons with somata >25 microM were studied because 80% of them stained positively for choline acetyltransferase and had electrophysiological characteristics identical to those of cholinergic NB neurons previously recorded in basal forebrain slices. Calcium currents of cholinergic NB neurons first were dissected pharmacologically into an amiloride-sensitive LVA and at least five subtypes of HVA currents. Approximately 17% of the total HVA current was sensitive to nifedipine (3 microM), 35% to omega-conotoxin-GVIA (200-400 nM), 10% to omega-Agatoxin-IVA (100 nM), and 20% to omega-Agatoxin-IVA (300-500 nM), suggesting the presence of L-, N-, P-, and Q-type channels, respectively. A remaining current (R-type) resistant to these antagonists was blocked by cadmium (100-200 microM). We then assessed pharmacologically the role that LVA and HVA currents had in activating the apamin-insensitive AHP elicited by a long train of action potentials (sAHP) and the AHP evoked either by a short burst of action potentials or by a single action potential (mAHP) that is known to be apamin-sensitive. During sAHPs, approximately 60% of the hyperpolarization was activated by calcium flowing through N-type channels and approximately 20% through P-type channels, whereas T-, L-, and Q-type channels were not involved significantly. In contrast, during mAHPs, N- and T-type channels played key roles (approximately 60 and 30%, respectively), whereas L-, P-, and Q-type channels were not implicated significantly. It is concluded that in cholinergic NB neurons various subtypes of calcium channels can differentially activate the apamin-sensitive mAHP and the apamin-insensitive sAHP.
Indexed as
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9295377PMC6573441What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.