Evidence map›Paper›PMID 9294446›Full record

ArticleJournal of bacteriology1997

A crtB homolog essential for photochromogenicity in Mycobacterium marinum: isolation, characterization, and gene disruption via homologous recombination.

L Ramakrishnan, H T Tran, N A Federspiel, S Falkow

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Genomic and phenotypic characterization ofMicrobiology spectrum · 2024
    Article
  5. Review
  6. Pathogens (Basel, Switzerland) · 2023
    Article
  7. Diagnosis of Mycobacterium marinum infection based on photochromogenicity: a case report.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022
    Article
  8. Variable Number Tandem Repeat Profiling ofFrontiers in microbiology · 2022
    Article
  9. Article
  10. Article
  11. Mycobacterium marinum.Microbiology spectrum · 2017
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

L RamakrishnanDepartment of Microbiology and Immunology, Stanford University School of Medicine, California 94305-5402, USA. lalitar@cmgm.stanford.edu
H T Tran
N A Federspiel
S Falkow
Stanford University · US

Funding

GENETIC BASIS OF MYCOBACTERIAL INVASIONR01AI036396 · NIAID · UNIVERSITY OF WASHINGTON · PI RAMAKRISHNAN, LALITA · 1994 to 2014
$5.2M
NHGRI NIH HHS HG00205NIAID NIH HHS AI36396
6 · The paper itself

Abstract

A gene essential for light-induced pigment production was isolated from the photochromogen Mycobacterium marinum by heterologous complementation of an M. marinum cosmid library in the nonchromogen Mycobacterium smegmatis. This gene is part of an operon and homologous to the Streptomyces griseus and Myxococcus xanthus crtB genes encoding phytoene synthase. Gene replacement at this locus was achieved via homologous recombination, demonstrating that its expression is essential for photochromogenicity. The ease of targeted gene disruption in this pathogenic Mycobacterium allows for the dissection of the molecular basis of mycobacterial pathogenesis.

Indexed as

Alkyl and Aryl TransferasesGene Expression Regulation, BacterialGenes, BacterialAmino Acid SequenceCarotenoidsChromosome MappingDNA, BacterialGeranylgeranyl-Diphosphate GeranylgeranyltransferaseLightMolecular Sequence DataMutagenesis, InsertionalMycobacteriumPhytochromeRecombination, GeneticRestriction MappingSequence AlignmentAlkyl and Aryl TransferasesCarotenoidsDNA, BacterialGeranylgeranyl-Diphosphate GeranylgeranyltransferasePhytochromeTransferases

Identifiers

PMID9294446
PMCPMC179478
OpenAlexW2110196241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.