ArticleProceedings of the National Academy of Sciences of the United States of America1997
Hemato-lymphoid in vivo reconstitution potential of subpopulations derived from in vitro differentiated embryonic stem cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Embryoid bodies as a model system for exploring early human embryonic development.Journal of assisted reproduction and genetics · 2025Review
- Effects of Mesenchymal Stem Cell Derivatives on Hematopoiesis and Hematopoietic Stem Cells.Advanced pharmaceutical bulletin · 2017Review
- Concise Review: Recent Advances in the In Vitro Derivation of Blood Cell Populations.Stem cells translational medicine · 2016Review
- In vivo repopulating activity emerges at the onset of hematopoietic specification during embryonic stem cell differentiation.Stem cell reports · 2015Article
- Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells.The International journal of developmental biology · 2010Review
- Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse development.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Evaluation of in vitro cytotoxicity and paracellular permeability of intact monolayers with mouse embryonic stem cells.Toxicology in vitro : an international journal published in association with BIBRA · 2008Article
- Mouse Germ Cell Development in-vivo and in-vitro.Biomarker insights · 2007Article
- Why the apparent haste to clone humans?Journal of medical ethics · 2006Review
- Genesis of hematopoietic stem cells in vitro and in vivo: new insights into developmental maturation.International journal of hematology · 2005Review
- Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host disease.The Journal of experimental medicine · 2004Article
- Osteogenic Cells Derived From Embryonic Stem Cells Produced Bone Nodules in Three-Dimensional Scaffolds.Journal of biomedicine & biotechnology · 2004Article
- Aspects on properties, use and ethical considerations of embryonic stem cells - A short review.Cytotechnology · 2003Article
- In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Stem cell therapy and gene transfer for regeneration.Gene therapy · 2000Review
- Embryonic stem cell differentiation models: cardiogenesis, myogenesis, neurogenesis, epithelial and vascular smooth muscle cell differentiation in vitro.Cytotechnology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During differentiation in vitro, embryonic stem (ES) cells generate progenitors for most hemato-lymphoid lineages. We studied the developmental potential of two ES cell subpopulations that share the fetal stem cell antigen AA4.1 but differ in expression of the lymphoid marker B220 (CD45R). Upon transfer into lymphoid deficient mice, the B220+ population generated a single transient wave of IgM+ IgD+ B cells but failed to generate T cells. In contrast, transfer of the B220- fraction achieved long-term repopulation of both T and B lymphoid compartments and restored humoral and cell-mediated immune reactions in the recipients. To assess the hemato-lymphopoietic potential of ES cell subsets in comparison to their physiological counterparts, cotransplantation experiments with phenotypically homologous subsets of fetal liver cells were performed, revealing a more potent developmental capacity of the latter. The results suggest that multipotential and lineage-committed lymphoid precursors are generated during in vitro differentiation of ES cells and that both subsets can undergo complete final maturation in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.