Evidence map›Paper›PMID 9294196›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1997

Calx, a Na-Ca exchanger gene of Drosophila melanogaster.

E M Schwarz, S Benzer

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 202 citations in OpenAlex.

  1. Article
  2. Article
  3. Putative role of TMEM165 in congenital cardiomyopathies.Frontiers in molecular neuroscience · 2025
    Review
  4. Proteomic analysis of the sponge Aggregation Factor implicates an ancient toolkit for allorecognition and adhesion in animals.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Review
  7. Lighting Up CaCells · 2021
    Review
  8. Review
  9. CALX-CBD1 CaBiophysical journal · 2020
    Article
  10. Modulation of the cardiac NaCell calcium · 2020
    Review
  11. Rapid Release of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  12. Article
  13. Article
  14. TheFrontiers in cellular neuroscience · 2018
    Article
  15. Review
  16. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart.The Journal of physiology · 2015
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

E M SchwarzDivision of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
S Benzer
California Institute of Technology · US

Funding

HUMAN RETINAL HOMOLOGS OF DROSOPHILA EYE GENESR01EY009278 · NEI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BENZER, SEYMOUR · 1991 to 2000
$298k
GENES MAINTAINING NERVOUS SYSTEM INTEGRITY DURING AGINGR01AG012289 · NIA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BENZER, SEYMOUR · 1994 to 1998
–
NEI NIH HHS EY09278NIA NIH HHS AG12289
6 · The paper itself

Abstract

We have cloned Calx, a gene that encodes a Na-Ca exchanger of Drosophila melanogaster. Calx encodes two repeated motifs, Calx-alpha and Calx-beta, that overlap domains required for exchanger activity and regulation. Calx has multiple transcripts in adults, including at least one expressed in the retina. The Calx genomic locus comprises >/=35 kb between the Atpalpha and rudimentary-like genes in chromosomal region 93B. In Xenopus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+ exchanger of mammalian heart. Implications of Calx-alpha motifs for the mechanism of Na-Ca exchange are discussed.

Indexed as

AntiportersDrosophila ProteinsAmino Acid SequenceAnimalsCarrier ProteinsCloning, MolecularDNA, ComplementaryDrosophila melanogasterMolecular Sequence DataSequence Homology, Amino AcidAntiportersCalx protein, DrosophilaCarrier ProteinsDNA, ComplementaryDrosophila Proteins

Identifiers

PMID9294196
PMCPMC23348
OpenAlexW2170680714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.