ArticleProceedings of the National Academy of Sciences of the United States of America1997
Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
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- Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation "Memories".EBioMedicine · 2016Article
- Widespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2.Epigenetics & chromatin · 2016Article
- Stem cell activation in skeletal muscle regeneration.Cellular and molecular life sciences : CMLS · 2015Review
- Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases.BioMed research international · 2015Review
- Long noncoding RNAs, emerging players in muscle differentiation and disease.Skeletal muscle · 2014Article
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- Different epigenetic alterations are associated with abnormal IGF2/Igf2 upregulation in neural tube defects.PloS one · 2014Article
- H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Evf2 (Dlx6as) lncRNA regulates ultraconserved enhancer methylation and the differential transcriptional control of adjacent genes.Development (Cambridge, England) · 2013Article
- Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status.PloS one · 2012Article
- Long-range chromatin interactions at the mouse Igf2/H19 locus reveal a novel paternally expressed long non-coding RNA.Nucleic acids research · 2011Article
- A non-coding RNA within the Rasgrf1 locus in mouse is imprinted and regulated by its homologous chromosome in trans.PloS one · 2010Article
- A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression.Molecular and cellular biology · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent investigations have shown that the maintenance of genomic imprinting of the murine insulin-like growth factor 2 (Igf2) gene involves at least two factors: the DNA (cytosine-5-)-methyltransferase activity, which is required to preserve the paternal specific expression of Igf2, and the H19 gene (lying 90 kb downstream of Igf2 gene), which upon inactivation leads to relaxation of the Igf2 imprint. It is not yet clear how these two factors are related to each other in the process of maintenance of Igf2 imprinting and, in particular, whether the latter is acting through cis elements or whether the H19 RNA itself is involved. By using Southern blots and the bisulfite genomic-sequencing technique, we have investigated the allelic methylation patterns (epigenotypes) of the Igf2 gene in two strains of mouse with distinct deletions of the H19 gene. The results show that maternal transmission of H19 gene deletions leads the maternal allele of Igf2 to adopt the epigenotype of the paternal allele and indicate that this phenomenon is influenced directly or indirectly by the H19 gene expression. More importantly, the bisulfite genomic-sequencing allowed us to show that the methylation pattern of the paternal allele of the Igf2 gene is affected in trans by deletions of the active maternal allele of the H19 gene. Selection during development for the appropriate expression of Igf2, dosage-dependent factors that bind to the Igf2 gene, or methylation transfer between the parental alleles could be involved in this trans effect.
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